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Mouse Anti-BHLHA15 Recombinant Antibody (CBYY-0532) (CBMAB-0535-YY)

This product is mouse antibody that recognizes BHLHA15. The antibody CBYY-0532 can be used for immunoassay techniques such as: WB, IHC-P, C
See all BHLHA15 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-0532
Antibody Isotype
IgG2b, κ
Application
WB, IF, IP, ELISA, IHC-P

Basic Information

Immunogen
Amino acids 63-102 mapping within an internal region of MIST1 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
IHC-P1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
N-Terminus

Target

Full Name
basic helix-loop-helix family, member a15
Introduction
Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-Bovinex occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-Bovinex consensus sequence 5-CANNTG-3 (By similarity).
Entrez Gene ID
Human168620
Mouse17341
UniProt ID
HumanQ7RTS1
MouseQ9QYC3
Alternative Names
Basic Helix-Loop-Helix Family Member A15; Basic Helix-Loop-Helix Domain Containing, Class B, 8; Muscle, Intestine And Stomach Expression 1; Class B Basic Helix-Loop-Helix Protein 8; BHLHB8; MIST-1;
Function
Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).
Biological Process
Calcium-mediated signaling Source: Ensembl
Cell-cell signaling Source: Ensembl
Cell maturation Source: Ensembl
Cellular response to glucose starvation Source: UniProtKB
Endoplasmic reticulum unfolded protein response Source: UniProtKB
Glucose homeostasis Source: Ensembl
Golgi organization Source: Ensembl
G protein-coupled receptor signaling pathway Source: Ensembl
Intracellular distribution of mitochondria Source: Ensembl
Mitochondrial calcium ion transmembrane transport Source: Ensembl
Negative regulation of myotube differentiation Source: UniProtKB
Neuron differentiation Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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