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BTRC

BTRC is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. BTRC belongs to the Fbws class; in addition to an F-box, it contains multiple WD-40 repeats. BTRC mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B.
Full Name
Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase
Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:25503564, PubMed:25704143, PubMed:9859996, PubMed:22087322).
SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (PubMed:12077367, PubMed:12820959).
SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 (PubMed:10835356, PubMed:11238952, PubMed:14681206, PubMed:14603323).
SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10066435, PubMed:10497169, PubMed:10644755).
Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10066435).
SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25704143, PubMed:25503564).
SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity).
Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:15917222).
May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3 (PubMed:16371461).
Mediates ubiquitination of REST, thereby leading to its proteasomal degradation (PubMed:21258371, PubMed:18354482).
Biological Process
Branching involved in mammary gland duct morphogenesis Source: Ensembl
Cellular response to organic cyclic compound Source: Ensembl
Fc-epsilon receptor signaling pathway Source: Reactome
G2/M transition of mitotic cell cycle Source: Reactome
Interleukin-1-mediated signaling pathway Source: Reactome
Mammary gland epithelial cell proliferation Source: Ensembl
Negative regulation of DNA-binding transcription factor activity Source: BHF-UCL
Negative regulation of smoothened signaling pathway Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
NIK/NF-kappaB signaling Source: Reactome
Positive regulation of circadian rhythm Source: UniProtKB
Positive regulation of proteolysis Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of ubiquitin protein ligase activity Source: ParkinsonsUK-UCL
Post-translational protein modification Source: Reactome
Proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
Protein dephosphorylation Source: UniProtKB
Protein destabilization Source: UniProtKB
Protein K48-linked ubiquitination Source: Ensembl
Protein polyubiquitination Source: ParkinsonsUK-UCL
Protein ubiquitination Source: UniProtKB
Regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Regulation of circadian rhythm Source: UniProtKB
Regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
Regulation of mitotic cell cycle phase transition Source: Reactome
Regulation of proteasomal protein catabolic process Source: Ensembl
Rhythmic process Source: UniProtKB-KW
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Signal transduction Source: ProtInc
Stimulatory C-type lectin receptor signaling pathway Source: Reactome
Stress-activated MAPK cascade Source: Reactome
T cell receptor signaling pathway Source: Reactome
Ubiquitin-dependent protein catabolic process Source: UniProtKB
Viral process Source: UniProtKB-KW
Wnt signaling pathway Source: Reactome
Cellular Location
Cytoplasm; Nucleus

Anti-BTRC antibodies

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Target: BTRC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-1051
Application*: E, IP, WB
Target: BTRC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-0936
Application*: WB, IF
Target: BTRC
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-0935
Application*: WB, IF, F
Target: BTRC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-0934
Application*: WB
Target: BTRC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-0933
Application*: WB, F
Target: BTRC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-0932
Application*: WB
Target: BTRC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-0931
Application*: WB, IF
Target: BTRC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-0930
Application*: IF, WB
Target: BTRC
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-0929
Application*: F, IF, WB
Target: BTRC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-0928
Application*: WB
Target: BTRC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-0927
Application*: F, WB
Target: BTRC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: CBYY-0926
Application*: E, F, IC, IF, IP, WB
Target: BTRC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1902
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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