ELISA, FC, ICC, IF, IP, WB
Recombinant human beta-TrCP fusion protein
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
This gene encodes a member of the F-Bovinex protein family which is characterized by an approximately 40 amino acid motif, the F-Bovinex. The F-Bovinex proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-Bovinex), which function in phosphorylation-dependent ubiquitination. The F-Bovinex proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-Bovinex, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]
Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase; F-Bovinex And WD Repeats Protein Beta-TrCP; PIkappaBalpha-E3 Receptor Subunit; Epididymis Tissue Protein Li 2a; E3RSIkappaB; FBXW1A; BTrCP; FBW1A; F-Bovinex/WD Repeat-Containing Protein 1A;