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C1QA

This gene encodes the A-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. Alternate splicing results in multiple transcript variants.

Full Name

C1QA

Function

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

Biological Process

Aging Source: ARUK-UCL
Astrocyte activation Source: ARUK-UCL
Cell-cell signaling Source: ProtInc
Complement activation Source: Reactome
Complement activation, classical pathway Source: Reactome
Complement-mediated synapse pruning Source: ARUK-UCL
Innate immune response Source: UniProtKB-KW
Microglial cell activation Source: ARUK-UCL
Neuron remodeling Source: ARUK-UCL
Positive regulation of neuron death Source: ARUK-UCL
Regulation of complement activation Source: Reactome
Response to iron ion Source: Ensembl
Synapse organization Source: ARUK-UCL
Synapse pruning Source: ARUK-UCL
Vertebrate eye-specific patterning Source: ARUK-UCL
Viral process Source: UniProtKB-KW

Cellular Location

Secreted

Involvement in disease

Complement component C1q deficiency (C1QD): A disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

PTM

O-linked glycans are assumed to be the Glc-Gal disaccharides typically found as secondary modifications of hydroxylated lysines in collagen-like domains.

Anti-C1QA antibodies

Mouse Anti-C1QA Recombinant Antibody (JL-1) (CBMAB-1235-CN)

SDS

Target: C1QA

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Mouse, Rat, Human

Clone: JL-1

Application*: E, FN, IC, IF, C, WB

Rat Anti-C1QA Recombinant Antibody (7H8) (CBMAB-1234-CN)

SDS

Target: C1QA

Host: Rat

Antibody Isotype: IgG1, κ

Specificity: Mouse, Human

Clone: 7H8

Application*: E, FN, IC, IF, C

Mouse Anti-C1QA Recombinant Antibody (CBFYA-0047) (CBMAB-X0074-FY)

SDS

Target: C1QA

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: CBFYA-0047

Application*: C, FN, IA, IF, WB

Rat Anti-C1QA Recombinant Antibody (CBFYA-0018) (CBMAB-X0029-FY)

SDS

Target: C1QA

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBFYA-0018

Application*: C, IA, IF

Rabbit Anti-C1QA Monoclonal Antibody (4.8) (CBMAB-0947-YC)

SDS

Target: C1QA

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: 4.8

Application*: P

Recombinant Mouse Anti-C1QA Antibody (CBHb074) (CBMAB-Hb081-LY)

SDS

Target: C1QA

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Mouse, Human, Rat

Clone: CBHb074

Application*: IHC-F, FuncS, Immuno assays, IF, WB

Recombinant Rat Anti-C1QA Antibody (CBHb031) (CBMAB-Hb080-LY)

SDS

Target: C1QA

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBHb031

Application*: IHC-F, Immuno assays, IF

Mouse Anti-C1QA Recombinant Antibody (MhC5B10) (CBMAB-C9521-LY)

SDS

Target: C1QA

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: MhC5B10

Application*: IF

Rat Anti-C1QA Recombinant Antibody (RmC7H8) (CBMAB-C9520-LY)

SDS

Target: C1QA

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: RmC7H8

Application*: IF, F

Mouse Anti-C1QA Recombinant Antibody (MhC5B9) (CBMAB-C9519-LY)

SDS

Target: C1QA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: MhC5B9

Application*: IF

Mouse Anti-C1QA Recombinant Antibody (CBCNC-126) (CBMAB-C1117-CN)

SDS

Target: C1QA

Host: Mouse

Specificity: Rat

Clone: CBCNC-126

Application*: WB, ICC, P, IH-F, E

Rat Anti-C1QA Recombinant Antibody (CBCNC-125) (CBMAB-C1116-CN)

SDS

Target: C1QA

Host: Rat

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBCNC-125

Application*: E, WB

Mouse Anti-C1QA Recombinant Antibody (CBCNC-124) (CBMAB-C1115-CN)

SDS

Target: C1QA

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBCNC-124

Application*: E, FN, WB

Mouse Anti-C1QA Recombinant Antibody (CBCNC-123) (CBMAB-C1114-CN)

SDS

Target: C1QA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBCNC-123

Application*: E, FN, WB

Mouse Anti-C1QA Recombinant Antibody (CBCNC-122) (CBMAB-C1113-CN)

SDS

Target: C1QA

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Rat

Clone: CBCNC-122

Application*: C, WB

Mouse Anti-C1QA Recombinant Antibody (9j110) (CBMAB-C1111-CN)

SDS

Target: C1QA

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 9j110

Application*: E, WB

Mouse Anti-C1QA Recombinant Antibody (CBYY-C2401) (CBMAB-C3839-YY)

SDS

Target: C1QA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C2401

Application*: IH, WB

Mouse Anti-C1QA Recombinant Antibody (CBXC-2526) (CBMAB-C5950-CQ)

SDS

Target: C1QA

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXC-2526

Application*: E, WB

Mouse Anti-C1QA Recombinant Antibody (CBXC-2879) (CBMAB-C5946-CQ)

SDS

Target: C1QA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-2879

Application*: E, F, C

Rat Anti-C1QA Recombinant Antibody (CBXC-1703) (CBMAB-C5928-CQ)

SDS

Target: C1QA

Host: Rat

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXC-1703

Application*: E, WB

Rat Anti-C1QA Recombinant Antibody (CBXC-1656) (CBMAB-C5926-CQ)

SDS

Target: C1QA

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBXC-1656

Application*: E, IF, IH

Mouse Anti-C1QA Recombinant Antibody (CBYY-C3182) (CBMAB-C4625-YY)

SDS

Target: C1QA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C3182

Application*: E, WB

Rat Anti-C1QA Recombinant Antibody (CBYY-C3119) (CBMAB-C4562-YY)

SDS

Target: C1QA

Host: Rat

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-C3119

Application*: WB

Rat Anti-C1QA Recombinant Antibody (CBYY-C0685) (CBMAB-C2017-YY)

SDS

Target: C1QA

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBYY-C0685

Application*: WB

Mouse Anti-C1QA Recombinant Antibody (3R9/2) (CBMAB-C0575-YY)

SDS

Target: C1QA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3R9/2

Application*: WB, F, E, IH, IF, C

Mouse Anti-C1QA Recombinant Antibody (5F91) (CBMAB-C7646-LY)

SDS

Target: C1QA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5F91

Application*: E, WB

Rat Anti-C1QA Recombinant Antibody (394107) (CBMAB-C5610-LY)

SDS

Target: C1QA

Host: Rat

Antibody Isotype: IgG2b

Specificity: Human

Clone: 394107

Application*: WB

Mouse Anti-C1QA Recombinant Antibody (242G3) (CBMAB-C4468-LY)

SDS

Target: C1QA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 242G3

Application*: E, I, WB

C1QA Matched Antibody Pair (154) (APMAB-154LY)

SDS

Target: C1QA

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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