Mouse Anti-C1QA Recombinant Antibody (CBT4829) (V2LY-0625-LY596)

Name: Mouse Anti-C1QA Recombinant Antibody (CBT4829)
SKU: V2LY-0625-LY596
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-C1QA Recombinant Antibody (CBT4829) (V2LY-0625-LY596) in ELISA

Mouse Anti-C1QA Recombinant Antibody (CBT4829) (V2LY-0625-LY596) in WB

Mouse Anti-C1QA Recombinant Antibody (CBT4829) (V2LY-0625-LY596) in FC

Mouse Anti-C1QA Recombinant Antibody (CBT4829) (V2LY-0625-LY596) in IHC

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT4829

Application

IHC, FC

Immunogen

Purified recombinant fragment of human C1QA (AA: 23-167) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

C1QA

Entrez Gene ID

712

UniProt ID

P02745

Function

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

Biological Process

Aging Source: ARUK-UCL
Astrocyte activation Source: ARUK-UCL
Cell-cell signaling Source: ProtInc
Complement activation Source: Reactome
Complement activation, classical pathway Source: Reactome
Complement-mediated synapse pruning Source: ARUK-UCL
Innate immune response Source: UniProtKB-KW
Microglial cell activation Source: ARUK-UCL
Neuron remodeling Source: ARUK-UCL
Positive regulation of neuron death Source: ARUK-UCL
Regulation of complement activation Source: Reactome
Response to iron ion Source: Ensembl
Synapse organization Source: ARUK-UCL
Synapse pruning Source: ARUK-UCL
Vertebrate eye-specific patterning Source: ARUK-UCL
Viral process Source: UniProtKB-KW

Cellular Location

Secreted

Involvement in disease

Complement component C1q deficiency (C1QD): A disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

PTM

O-linked glycans are assumed to be the Glc-Gal disaccharides typically found as secondary modifications of hydroxylated lysines in collagen-like domains.

Chen, L. H., Liu, J. F., Lu, Y., He, X. Y., Zhang, C., & Zhou, H. H. (2021). Complement C1q (C1qA, C1qB, and C1qC) May Be a Potential Prognostic Factor and an Index of Tumor Microenvironment Remodeling in Osteosarcoma. Frontiers in oncology, 11, 1643.

Mamoor, S. (2021). Chain A, B, and C of the complement component C1q are differentially expressed in human epithelial ovarian cancer.

Brym, P., Zabolewicz, T., & Kaminski, S. (2018). Differential expression of complement subcomponent C1qA in blood samples of healthy and BLV-infected Polish Holstein-Friesian cows. Anim Sci Pap Rep, 36, 45-55.

Fonseca, M. I., Chu, S. H., Hernandez, M. X., Fang, M. J., Modarresi, L., Selvan, P., ... & Tenner, A. J. (2017). Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain. Journal of neuroinflammation, 14(1), 1-15.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

C1QA Matched Antibody Pair (154) (CAT#: APMAB-154LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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