CALCR

This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Full Name

Calcitonin Receptor

Function

This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.
Isoform 2:
Receptor for calcitonin but is unable to couple to G proteins and activate adenylyl cyclase (PubMed:7476993).
Does not undergo receptor internalization following ligand binding (PubMed:7476993).

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
Amylin receptor signaling pathway Source: UniProtKB
Cell surface receptor signaling pathway Source: InterPro
Cross-receptor inhibition within G protein-coupled receptor heterodimer Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Positive regulation of adenylate cyclase activity Source: UniProtKB
Positive regulation of calcium ion import across plasma membrane Source: ARUK-UCL
Positive regulation of cell death Source: ARUK-UCL
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of peptidyl-serine phosphorylation Source: ARUK-UCL
Positive regulation of protein kinase A signaling Source: ARUK-UCL
Positive regulation of protein kinase B signaling Source: ARUK-UCL
Response to amyloid-beta Source: ARUK-UCL
Response to glucocorticoid Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 25-152 aa
Helical: 153-173 aa
Cytoplasmic: 174-186 aa
Helical: 187-207 aa
Extracellular: 208-233 aa
Helical: 234-254 aa
Cytoplasmic: 255-258 aa
Helical: 259-279 aa
Extracellular: 280-296 aa
Helical: 297-317 aa
Cytoplasmic: 318-340 aa
Helical: 341-361 aa
Extracellular: 362-373 aa
Helical: 374-394 aa
Cytoplasmic: 395-474 aa