CAMLG

CAMLG (Calcium Modulating Ligand) is a Protein Coding gene. Diseases associated with CAMLG include Cogan-Reese Syndrome. Among its related pathways are RANK Signaling in Osteoclasts and Ca, cAMP and Lipid Signaling. Gene Ontology (GO) annotations related to this gene include cell adhesion molecule binding.

Calcium Modulating Ligand

Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287, PubMed:24392163, PubMed:27226539).
Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287, PubMed:24392163, PubMed:27226539).
Required for the stability of GET1 (PubMed:32187542).
Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed:7522304).
Essential for the survival of peripheral follicular B cells (By similarity).

B cell homeostasis Source: UniProtKB
Defense response Source: ProtInc
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Negative regulation of protein ubiquitination Source: UniProtKB
Protein stabilization Source: UniProtKB
Signal transduction Source: ProtInc
Tail-anchored membrane protein insertion into ER membrane Source: UniProtKB
Viral process Source: UniProtKB-KW

Endoplasmic reticulum membrane

Cytoplasmic: 1-189 aa
Helical: 190-207 aa
Lumenal: 208-212 aa
Helical: 213-231 aa
Cytoplasmic: 232-269 aa
Helical: 270-288 aa
Lumenal: 289-296 aa