CAMLG

CAMLG (Calcium Modulating Ligand) is a Protein Coding gene. Diseases associated with CAMLG include Cogan-Reese Syndrome. Among its related pathways are RANK Signaling in Osteoclasts and Ca, cAMP and Lipid Signaling. Gene Ontology (GO) annotations related to this gene include cell adhesion molecule binding.
Full Name
Calcium Modulating Ligand
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287, PubMed:24392163, PubMed:27226539).
Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287, PubMed:24392163, PubMed:27226539).
Required for the stability of GET1 (PubMed:32187542).
Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed:7522304).
Essential for the survival of peripheral follicular B cells (By similarity).
Biological Process
B cell homeostasis Source: UniProtKB
Defense response Source: ProtInc
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Negative regulation of protein ubiquitination Source: UniProtKB
Protein stabilization Source: UniProtKB
Signal transduction Source: ProtInc
Tail-anchored membrane protein insertion into ER membrane Source: UniProtKB
Viral process Source: UniProtKB-KW
Cellular Location
Endoplasmic reticulum membrane
Topology
Cytoplasmic: 1-189 aa
Helical: 190-207 aa
Lumenal: 208-212 aa
Helical: 213-231 aa
Cytoplasmic: 232-269 aa
Helical: 270-288 aa
Lumenal: 289-296 aa
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Anti-CAMLG antibodies

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Rabbit Anti-CAMLG Recombinant Antibody (D5L9J) (CBMAB-CP0089-LY)

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Target: CAMLG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Hamster, Monkey
Clone: D5L9J
Application*: WB, IP
Datasheet SDS

Mouse Anti-CAMLG Recombinant Antibody (3F12) (CBMAB-C6007-LY)

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Target: CAMLG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3F12
Application*: WB, IF, E
Datasheet SDS

Mouse Anti-CAMLG Recombinant Antibody (2H3) (CBMAB-C5258-LY)

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Target: CAMLG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2H3
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-CAMLG Recombinant Antibody (1H3) (CBMAB-C4237-LY)

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Target: CAMLG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1H3
Application*: F, IF, WB
Datasheet SDS

CAMLG Matched Antibody Pair (179) (APMAB-179LY)

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Target: CAMLG
Specificity: Human
Datasheet SDS

Mouse Anti-CAMLG Recombinant Antibody (CBFYC-0780) (CBMAB-C0835-FY)

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Target: CAMLG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Pig
Clone: CBFYC-0780
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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