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Mouse Anti-CAMLG Recombinant Antibody (2H3) (CBMAB-C5258-LY)

This product is antibody recognizes CAMLG. The antibody 2H3 immunoassay techniques such as: FC, IF, WB.
See all CAMLG antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2H3
Antibody Isotype
IgG1
Application
FC, IF, WB

Basic Information

Immunogen
CAMLG antibody was raised in Mouse using full length human recombinant protein of human CAMLG produced in HEK293T cell as the immunogen
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5-1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Calcium Modulating Ligand
Introduction
CAMKV (CaM Kinase Like Vesicle Associated) is a Protein Coding gene. Diseases associated with CAMKV include Aleutian Mink Disease. Among its related pathways are Development EGFR signaling pathway and B Cell Receptor Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.
An important paralog of this gene is CAMK1G.
Entrez Gene ID
819
UniProt ID
P49069
Alternative Names
Calcium Modulating Ligand; Calcium-Modulating Cyclophilin Ligand; Cyclophilin B-Binding Protein; CAML; Calcium-Signal Modulating Cyclophilin Ligand; Calcium Signal-Modulating Cyclophilin Ligand; GET2;
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287, PubMed:24392163, PubMed:27226539).
Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287, PubMed:24392163, PubMed:27226539).
Required for the stability of GET1 (PubMed:32187542).
Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed:7522304).
Essential for the survival of peripheral follicular B cells (By similarity).
Biological Process
B cell homeostasis Source: UniProtKB
Defense response Source: ProtInc
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Negative regulation of protein ubiquitination Source: UniProtKB
Protein stabilization Source: UniProtKB
Signal transduction Source: ProtInc
Tail-anchored membrane protein insertion into ER membrane Source: UniProtKB
Viral process Source: UniProtKB-KW
Cellular Location
Endoplasmic reticulum membrane
Topology
Cytoplasmic: 1-189 aa
Helical: 190-207 aa
Lumenal: 208-212 aa
Helical: 213-231 aa
Cytoplasmic: 232-269 aa
Helical: 270-288 aa
Lumenal: 289-296 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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