Mouse Anti-CAMLG Recombinant Antibody (CBFYC-0780) (CBMAB-C0835-FY)

Name: Mouse Anti-CAMLG Recombinant Antibody (CBFYC-0780)
SKU: CBMAB-C0835-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-0780

Application

WB, IP, IF, ELISA

Immunogen

N-terminus of CAML of human origin.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Horse, Dog, Cattle, Pig

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA	1:100-1:1,000
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Calcium Modulating Ligand

Introduction

CAMLG (Calcium Modulating Ligand) is a Protein Coding gene. Diseases associated with CAMLG include Cogan-Reese Syndrome. Among its related pathways are RANK Signaling in Osteoclasts and Ca, cAMP and Lipid Signaling. Gene Ontology (GO) annotations related to this gene include cell adhesion molecule binding.

Entrez Gene ID

819

UniProt ID

P49069

Alternative Names

Calcium Modulating Ligand; Calcium-Modulating Cyclophilin Ligand; Cyclophilin B-Binding Protein; CAML; Calcium-Signal Modulating Cyclophilin Ligand; Calcium Signal-Modulating Cyclophilin Ligand; GET2

Function

Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287, PubMed:24392163, PubMed:27226539).
Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287, PubMed:24392163, PubMed:27226539).
Required for the stability of GET1 (PubMed:32187542).
Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed:7522304).
Essential for the survival of peripheral follicular B cells (By similarity).

Biological Process

B cell homeostasis Source: UniProtKB
Defense response Source: ProtInc
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Negative regulation of protein ubiquitination Source: UniProtKB
Protein stabilization Source: UniProtKB
Signal transduction Source: ProtInc
Tail-anchored membrane protein insertion into ER membrane Source: UniProtKB
Viral process Source: UniProtKB-KW

Cellular Location

Endoplasmic reticulum membrane

Topology

Cytoplasmic: 1-189 aa
Helical: 190-207 aa
Lumenal: 208-212 aa
Helical: 213-231 aa
Cytoplasmic: 232-269 aa
Helical: 270-288 aa
Lumenal: 289-296 aa

Gladue, D. P., Largo, E., Holinka, L. G., Ramirez-Medina, E., Vuono, E. A., Berggren, K. A., ... & Borca, M. V. (2018). Classical swine fever virus p7 protein interacts with host protein CAMLG and regulates calcium permeability at the endoplasmic reticulum. Viruses, 10(9), 460.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

CAMLG Matched Antibody Pair (179) (CAT#: APMAB-179LY)

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Mouse Anti-CAMLG Recombinant Antibody (2H3) (CAT#: CBMAB-C5258-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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