CCDC36

CCDC36 (Coiled-Coil Domain Containing 36) is a Protein Coding gene.

Coiled-Coil Domain Containing 36

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

DNA recombination Source: UniProtKB-KW
Homologous chromosome pairing at meiosis Source: UniProtKB
Meiotic DNA double-strand break formation Source: UniProtKB
Oogenesis Source: UniProtKB
Regulation of homologous chromosome segregation Source: UniProtKB
Spermatogenesis Source: UniProtKB

Chromosome. Specifically localizes to unsynapsed chromosomal regions during meiosis.