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CCDC36

CCDC36 (Coiled-Coil Domain Containing 36) is a Protein Coding gene.

Full Name

Coiled-Coil Domain Containing 36

Function

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

Biological Process

DNA recombination Source: UniProtKB-KW
Homologous chromosome pairing at meiosis Source: UniProtKB
Meiotic DNA double-strand break formation Source: UniProtKB
Oogenesis Source: UniProtKB
Regulation of homologous chromosome segregation Source: UniProtKB
Spermatogenesis Source: UniProtKB

Cellular Location

Chromosome. Specifically localizes to unsynapsed chromosomal regions during meiosis.

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Anti-CCDC36 antibodies

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Mouse Anti-CCDC36 Recombinant Antibody (2D11) (CBMAB-C4858-LY)

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Target: CCDC36

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2D11

Application*: WB, IH

Mouse Anti-CCDC36 Recombinant Antibody (CBFYC-0911) (CBMAB-C0967-FY)

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Target: CCDC36

Host: Mouse

Antibody Isotype: IgG1, λ

Specificity: Human, Mouse, Rat

Clone: CBFYC-0911

Application*: WB, IP, IF, E

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Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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