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CCL4

CCL4 (C-C Motif Chemokine Ligand 4) is a Protein Coding gene. Diseases associated with CCL4 include Pulmonary Tuberculosis and Meningitis. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include identical protein binding and chemokine activity. An important paralog of this gene is CCL4L2.
Full Name
C-C Motif Chemokine Ligand 4
Function
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Biological Process
Cell adhesion Source: ProtInc
Cell-cell signaling Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Cytokine-mediated signaling pathway Source: Reactome
Eosinophil chemotaxis Source: GO_Central
Establishment or maintenance of cell polarity Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Inflammatory response Source: GO_Central
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Negative regulation by host of viral transcription Source: UniProtKB
Neutrophil chemotaxis Source: GO_Central
Positive regulation of calcium ion transport Source: UniProtKB
Positive regulation of calcium-mediated signaling Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Positive regulation of natural killer cell chemotaxis Source: UniProtKB
Response to toxic substance Source: UniProtKB
Response to virus Source: ProtInc
Signal transduction Source: ProtInc
Cellular Location
Secreted
PTM
N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.
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Anti-CCL4 antibodies

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Rat Anti-CCL4 Recombinant Antibody (46907) (CBMAB-C1330-LY)

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Target: CCL4
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 46907
Application*: N
Functional Assay
Datasheet SDS

Mouse Anti-CCL4 Recombinant Antibody (163910) (CBMAB-C3323-LY)

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Target: CCL4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 163910
Application*: WB, N
Functional Assay
Datasheet SDS

Mouse Anti-CCL4 Recombinant Antibody (CBT2341) (V2LY-0625-LY1064)

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Target: CCL4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT2341
Application*: F
Datasheet SDS

Mouse Anti-CCL4 Recombinant Antibody (CBT3555) (V2LY-0625-LY1063)

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Target: CCL4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3555
Application*: WB
Datasheet SDS

Mouse Anti-CCL4 Recombinant Antibody (CBFYC-0483) (CBMAB-C0531-FY)

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Target: CCL4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-0483
Application*: E, WB, F
Datasheet SDS

Rabbit Anti-CCL4 Recombinant Antibody (CBFYC-0464) (CBMAB-C0510-FY)

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Target: CCL4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBFYC-0464
Application*: WB, IP, IF
Datasheet SDS

Rat Anti-CCL4 Recombinant Antibody (CBFYM-0945) (CBMAB-M1094-FY)

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Target: CCL4
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYM-0945
Application*: E, N
Functional Assay
Datasheet SDS

Mouse Anti-CCL4 Recombinant Antibody (CBFYM-0943) (CBMAB-M1092-FY)

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Target: CCL4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYM-0943
Application*: E, WB, IP, IF
Datasheet SDS

Mouse Anti-CCL4 Recombinant Antibody (CBFYM-0260) (CBMAB-M0325-FY)

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Target: CCL4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0260
Application*: E, WB, IP
Datasheet SDS

Mouse Anti-CCL4 Recombinant Antibody (24006) (CBMAB-C0709-LY)

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Target: CCL4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 24006
Application*: E, F, N, WB
Functional Assay
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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