CD300LF

CD300LF (CD300 Molecule Like Family Member F) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is CD300LD.

Full Name

CD300 Molecule Like Family Member F

Function

Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731).
Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity).
Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150).
May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity).
Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923).
Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity).

Biological Process

Immune system process Source: UniProtKB-KW
Interleukin-13-mediated signaling pathway Source: UniProtKB
Negative regulation of apoptotic cell clearance Source: UniProtKB
Negative regulation of mast cell activation Source: UniProtKB
Negative regulation of MyD88-dependent toll-like receptor signaling pathway Source: UniProtKB
Positive regulation of apoptotic cell clearance Source: UniProtKB
Positive regulation of interleukin-4-mediated signaling pathway Source: UniProtKB
Regulation of immune response Source: Reactome
TRIF-dependent toll-like receptor signaling pathway Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 20-156
Helical: 157-177
Cytoplasmic: 178-290

PTM

Phosphorylated on tyrosine.