CD300LF

CD300LF (CD300 Molecule Like Family Member F) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is CD300LD.
Full Name
CD300 Molecule Like Family Member F
Function
Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731).
Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity).
Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150).
May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity).
Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923).
Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity).
Biological Process
Immune system process Source: UniProtKB-KW
Interleukin-13-mediated signaling pathway Source: UniProtKB
Negative regulation of apoptotic cell clearance Source: UniProtKB
Negative regulation of mast cell activation Source: UniProtKB
Negative regulation of MyD88-dependent toll-like receptor signaling pathway Source: UniProtKB
Positive regulation of apoptotic cell clearance Source: UniProtKB
Positive regulation of interleukin-4-mediated signaling pathway Source: UniProtKB
Regulation of immune response Source: Reactome
TRIF-dependent toll-like receptor signaling pathway Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 20-156
Helical: 157-177
Cytoplasmic: 178-290
PTM
Phosphorylated on tyrosine.
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Anti-CD300LF antibodies

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Mouse Recombinant CD300LF protein, ECD, Fc Tag (V2LY-0526-LY7993)

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Target: CD300LF
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-193
Tag: Fc Tag
Datasheet SDS

Human Recombinant CD300F protein, His Tag (V2LY-0526-LY2796)

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Target: CD300LF
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-155
Tag: His Tag
Datasheet SDS

Human Recombinant CD300F protein, hFc Tag (V2LY-0526-LY2795)

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Target: CD300LF
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-155
Tag: hFc Tag
Datasheet SDS

Mouse Anti-CD300LF Recombinant Antibody (CBT4249) (V2LY-0625-LY1708)

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Target: CD300LF
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT4249
Application*: IH, F
Datasheet SDS

Mouse Anti-CD300LF Recombinant Antibody (CBT3542) (V2LY-0625-LY1707)

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Target: CD300LF
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3542
Application*: F
Datasheet SDS

Mouse Anti-CD300LF Recombinant Antibody (C2084) (CBMAB-C2084-CQ)

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Target: CD300LF
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: C2084
Application*: E
Datasheet SDS

Mouse Anti-CD300LF Recombinant Antibody (CBFYC-0457) (CBMAB-C0503-FY)

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Target: CD300LF
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-0457
Application*: F, IF, WB, E
Datasheet SDS

Rat Anti-CD300LF Recombinant Antibody (234903) (CBMAB-C0696-LY)

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Target: CD300LF
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 234903
Application*: WB, N, F, IF
Functional Assay
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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