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CD8A

CD8A (CD8a Molecule) is a Protein Coding gene. Diseases associated with CD8A include Cd8 Deficiency, Familial and Primary Cutaneous Aggressive Epidermotropic Cd8+ T-Cell Lymphoma. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and T-Cell Receptor and Co-stimulatory Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and coreceptor activity.
Full Name
CD8a Molecule
Function
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
Biological Process
Antigen processing and presentation Source: UniProtKB
Cell surface receptor signaling pathway Source: GO_Central
Cytotoxic T cell differentiation Source: GO_Central
Immune response Source: UniProtKB
Regulation of immune response Source: Reactome
T cell activation Source: UniProtKB
T cell mediated immunity Source: GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Cellular Location
Isoform 1: Cell membrane. CD8A localizes to lipid rafts only when associated with its partner CD8B.
Isoform 2: Secreted
Involvement in disease
CD8 deficiency, familial (CD8 deficiency): An immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
Topology
Extracellular: 22-182
Helical: 183-203
Cytoplasmic: 204-235
PTM
Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts.
O-glycosylated.
Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.

Anti-CD8A antibodies

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Target: CD8A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 105.18
Application*: Block, FC, IF, IHC
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14
Application*: ELISA, FC, IHC, IP
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 17D8
Application*: FC
Target: CD8A
Host: Goat
Antibody Isotype: IgG
Specificity: Human
Clone: HIT8a
Application*: FC
Target: CD8A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR044F
Application*: WB, IHC, IHC-IF, mIF
Target: CD8A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb059
Application*: WB, IH, IF
Target: CD8A
Host: Mouse
Specificity: Human
Clone: IHC542
Application*: IH
Target: CD8A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D8A8Y
Application*: WB, IP, P, F
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: OX8-2b
Application*: F
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: Rib6/1
Application*: F
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: R73-2b
Application*: C
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: ANK44
Application*: F
Target: CD8A
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: MAB0708
Application*: IH
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Chicken
Clone: CBLC280-LY
Application*: F
Target: CD8A
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 4AM43
Application*: F
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: MIH3
Application*: F
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: WT82
Application*: IC, IF
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog
Clone: TS106
Application*: IC
Target: CD8A
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human, Monkey
Clone: YTC 141.1HL
Application*: F
Target: CD8A
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: MAB0811
Application*: B, D
Target: CD8A
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: OX8-2
Application*: P, C, F
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: MM0178-3C39
Application*: F
Target: CD8A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP239
Application*: P
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rabbit
Clone: 7E109
Application*: F
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Pig
Clone: 5K107
Application*: F
Target: CD8A
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: KT15
Application*: C, IC/IF, F
Target: CD8A
Host: Mouse
Antibody Isotype: IgM
Specificity: Mouse
Clone: AD415
Application*: F
Target: CD8A
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: 2.43
Application*: F
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rabbit
Clone: 12.C7
Application*: F
Target: CD8A
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CT-CD8a
Application*: IH
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken
Clone: CT-8
Application*: F
Target: CD8A
Host: Mouse
Antibody Isotype: IgM
Specificity: Mouse
Clone: NYRmCD8
Application*: F
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: OX8
Application*: F
Target: CD8A
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: YTS169.4
Application*: F
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: UCHT-4
Application*: F
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: MRC OX-8
Application*: F
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: mAb 104
Application*: F
Target: CD8A
Host: Rabbit
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: YTS 105.18
Application*: C, IF/IC, C
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Duck
Clone: CBCNC-167
Application*: FC, IP
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Guinea Pig
Clone: CBCNC-166
Application*: FC
Target: CD8A
Host: Rat
Antibody Isotype: IgG1
Specificity: Dog
Clone: YCATE55-9
Application*: FC
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Guinea pig
Clone: CT6
Application*: IH, FC
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Ferret
Clone: 3B5H2
Application*: E
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cat
Clone: 13H198
Application*: FC, IH, IP
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Guinea pig
Clone: 10B1991
Application*: FC, IH
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Fish
Clone: V44P1H9/F11
Application*: E
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cat
Clone: fCD8
Application*: IH, C
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Horse
Clone: CVS8
Application*: FC
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Horse
Clone: CVS21
Application*: FC
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cat
Clone: 5K112
Application*: FC, IH, IP
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cat
Clone: 10B2013
Application*: C, F
Target: CD8A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Ferret
Clone: 080
Application*: E
Target: CD8A
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 07-06-53
Application*: C, FN, IP
Target: CD8A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 016
Application*: EC
Target: CD8A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 012
Application*: E
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 3H885
Application*: F, IH
Target: CD8A
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 3H870
Application*: F, IH
Target: CD8A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 208
Application*: F, IC/IF, IF
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Pig
Clone: 11-02-76
Application*: CT, F, IP
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBFYM-0982
Application*: IF, F
Target: CD8A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYR-0012
Application*: ELISA
Target: CD8A
Host: Rat
Antibody Isotype: IgG1
Specificity: Dog
Clone: YCATE55.9
Application*: F
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Pig
Clone: MIL12
Application*: F
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey
Clone: SK1
Application*: F
Target: CD8A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: N21-G
Application*: F
Target: CD8A
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: YTS 169AG 101HL
Application*: F
Target: CD8A
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human, Monkey
Clone: YTC141.1HL
Application*: IH, FC
Target: CD8A
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: YTC 182.20
Application*: FC
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: UCHT4
Application*: E, FC, IF, WB
Target: CD8A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP16
Application*: P
Target: CD8A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: S23-D
Application*: E, WB
Target: CD8A
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Monkey
Clone: FK18
Application*: IH, IF
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: B-Z31
Application*: P, FC
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7H224
Application*: FC, IF, WB
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5K61
Application*: FC, IH, IP
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5C25
Application*: IF
Target: CD8A
Host: Rabbit
Antibody Isotype: IgG2b
Specificity: Human, Monkey
Clone: 3H841
Application*: FC
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 15-11C5
Application*: FC, IH
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 14L234
Application*: FC
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 144B
Application*: P
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 13H200
Application*: FC, IH
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 11C95
Application*: E
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10K137
Application*: IH, IP
Target: CD8A
Host: Rabbit
Antibody Isotype: IgG2b
Specificity: Human
Clone: 10B1990
Application*: FC, IH
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B1989
Application*: FC
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5K62
Application*: FC, IH
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14
Application*: E, F, IH, IP
Target: CD8A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P040
Application*: WB, IC, P, C, E
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: V2-186959
Application*: E, IP
Target: CD8A
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H889
Application*: F, IH
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3H849
Application*: C, WB
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H6
Application*: P, WB
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 3C39
Application*: F
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 25
Application*: E
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 22
Application*: E
Target: CD8A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 143-44
Application*: F, C
Target: CD8A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 081
Application*: P
Target: CD8A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 07
Application*: ED
Target: CD8A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 01
Application*: EC
Target: CD8A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 28
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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