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CDC25C

CDC25C (Cell Division Cycle 25C) is a Protein Coding gene. Diseases associated with CDC25C include Plague and Prostate Cancer. Among its related pathways are Gene Expression and Akt Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and WW domain binding. An important paralog of this gene is CDC25B.

Full Name

Cell Division Cycle 25C

Function

Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.

Biological Process

Cell division Source: UniProtKB-KW
Cell population proliferation Source: ProtInc
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
G2/M transition of mitotic cell cycle Source: UniProtKB
Positive regulation of G2/MI transition of meiotic cell cycle Source: GO_Central
Positive regulation of G2/M transition of mitotic cell cycle Source: GO_Central
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
Regulation of mitotic nuclear division Source: ProtInc
Spermatogenesis Source: Ensembl
Viral process Source: UniProtKB-KW

Cellular Location

Nucleus

PTM

Phosphorylated by CHEK1 and MAPK14 at Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4. Phosphorylated by PLK1, leading to activate the phosphatase activity. Phosphorylation by PLK3 at Ser-191 promotes nuclear translocation. Ser-198 is a minor phosphorylation site. Was initially reported to be phosphorylated by PLK3 at Ser-216 (PubMed:10557092). However, such phosphorylation by PLK3 was not confirmed by other groups. Phosphorylation at Thr-48, Thr-67, Ser-122, Thr-130, Ser-168 and Ser-214 occurs at G2 and G2-M transition and is probably catalyzed by CDK1. Ser-168 phosphorylation levels are lower than those at the other 5 CDK1 sites. Phosphorylation by CDK1 leads to increased activity.

Anti-CDC25C antibodies

Mouse Anti-CDC25C Recombinant Antibody (CBXC-1993) (CBMAB-C4851-CQ)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-1993

Application*: E, WB, IH

Mouse Anti-CDC25C Recombinant Antibody (CBXC-0297) (CBMAB-C4850-CQ)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0297

Application*: E, P, WB

Mouse Anti-CDC25C Recombinant Antibody (CBFYC-1514) (CBMAB-C1573-FY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYC-1514

Application*: CI, IF, IH, IP, WB

Mouse Anti-CDC25C Recombinant Antibody (CBFYC-1513) (CBMAB-C1572-FY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1513

Application*: E, IH, WB

Mouse Anti-CDC25C Recombinant Antibody (CBFYC-1512) (CBMAB-C1571-FY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1512

Application*: DB, IC, IF, WB

Mouse Anti-CDC25C Recombinant Antibody (CBFYC-1511) (CBMAB-C1570-FY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYC-1511

Application*: E, P, WB

Mouse Anti-CDC25C Recombinant Antibody (CBFYC-0456) (CBMAB-C0502-FY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYC-0456

Application*: E, WB

Mouse Anti-CDC25C Recombinant Antibody (CBFYM-0985) (CBMAB-M1135-FY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYM-0985

Application*: WB

Rabbit Anti-CDC25C (Phosphorylated S216) Recombinant Antibody (63F9) (PTM-CBMAB-0434LY)

SDS

Target: CDC25C

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: 63F9

Application*: WB, IP, P

Mouse Anti-CDC25C Recombinant Antibody (1F12) (CBMAB-EN680-LY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 1F12

Application*: WB, IHC, ELISA

Mouse Anti-CDC25C Recombinant Antibody (CAP439) (CBMAB-AP1355LY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CAP439

Application*: WB

Mouse Anti-CDC25C Recombinant Antibody (CAP438) (CBMAB-AP1354LY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CAP438

Application*: IHC, WB

Mouse Anti-CDC25C Recombinant Antibody (DCS-193) (CBMAB-AP1352LY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: DCS-193

Application*: WB

Mouse Anti-CDC25C Recombinant Antibody (CBMAB-AO274LY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Application*: ELISA, WB

Recombinant Mouse Anti-CDC25C Antibody (CBAb061) (CBMAB-Ab061-LY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBAb061

Application*: WB, IH

Mouse Anti-CDC25C Recombinant Antibody (TC-19) (CBMAB-C10780-LY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: TC-19

Application*: IC/IF, IP, WB

Mouse Anti-CDC25C Recombinant Antibody (TC-113) (CBMAB-C10778-LY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: TC-113

Application*: IP, WB

Rabbit Anti-CDC25C Recombinant Antibody (CBNH-035) (CBMAB-R4360-CN)

SDS

Target: CDC25C

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBNH-035

Application*: E, WB, IH, IF, IP

Mouse Anti-CDC25C Recombinant Antibody (IMD-25) (CBMAB-C2033-CN)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: IMD-25

Application*: WB

Mouse Anti-CDC25C Recombinant Antibody (0.T.16) (CBMAB-C2029-CN)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 0.T.16

Application*: IF, IH, IP, WB

Mouse Anti-CDC25C Recombinant Antibody (CBYY-C1683) (CBMAB-C3121-YY)

SDS

Target: CDC25C

Host: Mouse

Specificity: Human

Clone: CBYY-C1683

Application*: WB

Rabbit Anti-CDC25C Recombinant Antibody (CBYY-C1682) (CBMAB-C3120-YY)

SDS

Target: CDC25C

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: CBYY-C1682

Application*: WB, IP, P

Rat Anti-CDC25C Recombinant Antibody (CBYY-C0239) (CBMAB-C0693-YY)

SDS

Target: CDC25C

Host: Rat

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBYY-C0239

Application*: WB

Rabbit Anti-CDC25C Recombinant Antibody (5H9) (CBMAB-C7743-LY)

SDS

Target: CDC25C

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 5H9

Application*: WB

Mouse Anti-CDC25C Recombinant Antibody (15B124) (CBMAB-C3235-LY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 15B124

Application*: WB

Mouse Anti-CDC25C Recombinant Antibody (13B150) (CBMAB-C2789-LY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 13B150

Application*: E, C, WB

Mouse Anti-CDC25C Recombinant Antibody (10K146) (CBMAB-C2375-LY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10K146

Application*: WB

Mouse Anti-CDC25C Recombinant Antibody (0.N.192) (CBMAB-C1401-LY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 0.N.192

Application*: IF, IP, WB

Rat Anti-CDC25C Recombinant Antibody (461908) (CBMAB-C1324-LY)

SDS

Target: CDC25C

Host: Rat

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 461908

Application*: WB

Mouse Anti-CDC25C Recombinant Antibody (25C14) (CBMAB-C0750-LY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 25C14

Application*: IF, IP, WB

Mouse Anti-CDC25C Recombinant Antibody (233CT9.6.6) (CBMAB-C0695-LY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 233CT9.6.6

Application*: E, WB

Mouse Anti-CDC25C Recombinant Antibody (2131C2a) (CBMAB-C0616-LY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2131C2a

Application*: DB, IC, IF, WB

Mouse Anti-CDC25C Recombinant Antibody (1535CT627.6.80) (CBMAB-C0356-LY)

SDS

Target: CDC25C

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1535CT627.6.80

Application*: E, P, WB

CDC25C Matched Antibody Pair (245) (APMAB-245LY)

SDS

Target: CDC25C

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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