CDCP1

CDCP1 (CUB Domain Containing Protein 1) is a Protein Coding gene. Diseases associated with CDCP1 include Colorectal Cancer. Among its related pathways are Wnt / Hedgehog / Notch and NF-kappaB Signaling.
Full Name
CUB Domain Containing Protein 1
Alternative Names
CUB Domain Containing Protein 1; Subtractive Immunization M Plus HEp3-Associated 135 KDa Protein; Transmembrane And Associated With Src Kinases; Membrane Glycoprotein Gp140; SIMA135; TRASK; CUB Domain-Containing Protein 1; CD318 Antigen; CD318;
Function
May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.
Biological Process
Isoform 1: Cell membrane. Shedding may also lead to a soluble peptide.
Isoform 3: Secreted
Topology
Extracellular: 30-667
Helical: 668-688
Cytoplasmic: 689-836
PTM
Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5.
N-glycosylated.
A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease.
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Anti-CDCP1 antibodies

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Mouse Anti-CDCP1 Recombinant Antibody (AG50) (V2LY-0524-LY101)

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Target: CDCP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: AG50
Application*: F
Datasheet SDS

Human Anti-CDCP1 Recombinant Antibody (
30D4) (V2LY-0725-LY1433)

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Target: CDCP1
Host: Human
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey
Clone: 30D4
Application*: E
Datasheet SDS

Mouse Anti-CDCP1 Recombinant Antibody (CBT2308) (V2LY-0625-LY605)

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Target: CDCP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2308
Application*: IH
Datasheet SDS

Human Anti-CDCP1 Recombinant Antibody (CBXC-1088) (CBMAB-C5745-CQ)

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Target: CDCP1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1088
Application*: F, E
Datasheet SDS

Rat Anti-CDCP1 Recombinant Antibody (CBXC-1699) (CBMAB-C3591-CQ)

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Target: CDCP1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-1699
Application*: WB
Datasheet SDS

Human Anti-CDCP1 Recombinant Antibody (CBXC-0736) (CBMAB-C1850-CQ)

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Target: CDCP1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0736
Application*: F, E
Datasheet SDS

Mouse Anti-CDCP1 Recombinant Antibody (CBXC-1086) (CBMAB-C1352-CQ)

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Target: CDCP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: CBXC-1086
Application*: F, in vivo
In Vivo Assay
Datasheet SDS

Mouse Anti-CDCP1 Recombinant Antibody (CBYY-C1702) (CBMAB-C3140-YY)

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Target: CDCP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: CBYY-C1702
Application*: F, in vivo
In Vivo Assay
Datasheet SDS

Mouse Anti-CDCP1 Recombinant Antibody (CBFYC-1536) (CBMAB-C1595-FY)

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Target: CDCP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYC-1536
Application*: F
Datasheet SDS

Rabbit Anti-CDCP1 Recombinant Antibody (CBFYC-1535) (CBMAB-C1594-FY)

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Target: CDCP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-1535
Application*: E
Datasheet SDS

Mouse Anti-CDCP1 Recombinant Antibody (CBFYC-1534) (CBMAB-C1593-FY)

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Target: CDCP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1534
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-CDCP1 Recombinant Antibody (040) (CBMAB-C1756-LY)

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Target: CDCP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 40
Application*: E
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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