Human Anti-CDCP1 Recombinant Antibody (CBXC-1088) (CBMAB-C5745-CQ)

Name: Human Anti-CDCP1 Recombinant Antibody (CBXC-1088)
SKU: CBMAB-C5745-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Human

Clone

CBXC-1088

Application

FC, ELISA

Immunogen

CDCP1/CD318.

Host Species

Human

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

8% sucrose, 0.01% Tween80

Preservative

None

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

CUB Domain Containing Protein 1

Introduction

CDCP1 (CUB Domain Containing Protein 1) is a Protein Coding gene. Diseases associated with CDCP1 include Colorectal Cancer. Among its related pathways are Wnt / Hedgehog / Notch and NF-kappaB Signaling.

Entrez Gene ID

64866

UniProt ID

Q9H5V8

Alternative Names

CUB Domain Containing Protein 1; Subtractive Immunization M Plus HEp3-Associated 135 KDa Protein; Transmembrane And Associated With Src Kinases; Membrane Glycoprotein Gp140; SIMA135; TRASK; CUB Domain-Containing Protein 1; CD318 Antigen; CD318;

Function

May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.

Biological Process

Isoform 1: Cell membrane. Shedding may also lead to a soluble peptide.
Isoform 3: Secreted

Topology

Extracellular: 30-667
Helical: 668-688
Cytoplasmic: 689-836

PTM

Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5.
N-glycosylated.
A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease.

Wang, M., Liu, D., Murthy, V., Nguyen, T. T., Lim, D. Y., Huang, R., ... & Pereira, N. (2021, May). ROLE AND FUNCTIONAL CHARACTERIZATION OF CUB-DOMAIN CONTAINING PROTEIN 1 (CDCP1) IN DILATED CARDIOMYOPATHY. In Journal of the American College of Cardiology (Vol. 77, No. 18, pp. 537-537). STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA: ELSEVIER SCIENCE INC.

Khan, T., Kryza, T., Lyons, N. J., He, Y., & Hooper, J. D. (2021). The CDCP1 Signaling Hub: A Target for Cancer Detection and Therapeutic Intervention. Cancer Research, 81(9), 2259-2269.

Mamoor, S. (2021). Over-expression of CUB domain containing protein 1 in human endometrial cancer.

Moroz, A., Wang, Y. H., Sharib, J. M., Wei, J., Zhao, N., Huang, Y., ... & Evans, M. J. (2020). Theranostic targeting of CUB domain containing protein 1 (CDCP1) in pancreatic cancer. Clinical Cancer Research, 26(14), 3608-3615.

Huang, L., Chen, Y., Lai, S., Guan, H., Hu, X., Liu, J., ... & Zhou, J. (2020). CUB Domain-Containing Protein-1 Promotes Proliferation, Migration and Invasion in Cervical Cancer Cells. Cancer management and research, 12, 3759.

Nelson, L. J., Wright, H. J., Dinh, N. B., Nguyen, K. D., Razorenova, O. V., & Heinemann, F. S. (2020). Src Kinase Is Biphosphorylated at Y416/Y527 and Activates the CUB-Domain Containing Protein 1/Protein Kinase C δ Pathway in a Subset of Triple-Negative Breast Cancers. The American journal of pathology, 190(2), 484-502.

Predes, D., Cruz, J. V. R., Abreu, J. G., & Mendes, F. A. (2019). CUB domain-containing protein 1 (CDCP1) binds transforming growth factor beta family members and increase TGF-β1 signaling pathway. Experimental cell research, 383(1), 111499.

Kajiwara, K., Sugihara, A., Aoki, K., Okuzaki, D., Matsumoto, K., & Okada, M. (2019). CUB domain-containing protein 1 controls HGF responses by integrating Src and Met–STAT3 signaling. bioRxiv, 789339.

Kuhara, K., Tokuda, K., Kitagawa, T., Baron, B., Tokunaga, M., Harada, K., ... & Kuramitsu, Y. (2018). CUB domain-containing protein 1 (CDCP1) is down-regulated by Active Hexose-Correlated Compound in human pancreatic cancer cells. Anticancer research, 38(11), 6107-6111.

Noskovičová, N., Heinzelmann, K., Burgstaller, G., Behr, J., & Eickelberg, O. (2018). Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation. American Journal of Physiology-Lung Cellular and Molecular Physiology, 314(5), L695-L707.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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