CHD4

The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Full Name
Chromodomain Helicase DNA Binding Protein 4
Function
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones.
Biological Process
ATP-dependent chromatin remodeling Source: UniProtKB
Regulation of signal transduction by p53 class mediator Source: Reactome
Regulation of transcription by RNA polymerase II Source: ProtInc
Cellular Location
Centrosome; Nucleus. Associates with centrosomes in interphase.
Involvement in disease
Sifrim-Hitz-Weiss syndrome (SIHIWES): An autosomal dominant syndrome characterized by mental retardation, variable congenital defects affecting cardiac, skeletal, and urogenital systems. Short stature, macrocephaly, hearing impairment, and facial dysmorphism are present in some patients.
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Anti-CHD4 antibodies

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Mouse Anti-CHD4 Recombinant Antibody (CF097) (CBMAB-FT375LY)

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Target: CHD4
Host: Mouse
Antibody Isotype: IgA, κ
Specificity: Human, Mouse, Rat, Dog, Pig, Horse
Clone: CF097
Application*: E, IF, IP, WB, P
Datasheet SDS

Mouse Anti-CHD4 Recombinant Antibody (
12C5) (V2LY-0725-LY251)

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Target: CHD4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 12C5
Application*: E, WB, IP
Datasheet SDS

Mouse Anti-CHD4 Recombinant Antibody (CBT3590) (V2LY-0625-LY1265)

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Target: CHD4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3590
Application*: WB
Datasheet SDS

Mouse Anti-CHD4 Recombinant Antibody (CAP497) (CBMAB-AP1492LY)

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Target: CHD4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CAP497
Application*: E, WB
Datasheet SDS

Mouse Anti-CHD4 Recombinant Antibody (CAP496) (CBMAB-AP1491LY)

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Target: CHD4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CAP496
Application*: WB
Datasheet SDS

Mouse Anti-CHD4 Recombinant Antibody (CB472A) (CBMAB-CA472LY)

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Target: CHD4
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat, Dog, Pig, Horse, Cattle
Clone: CB472A
Application*: E, IF, IP, WB, P
Datasheet SDS

Rabbit Anti-CHD4 Recombinant Antibody (CBWJC-2635) (CBMAB-C3720WJ)

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Target: CHD4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBWJC-2635
Application*: WB, P
Datasheet SDS

Mouse Anti-CHD4 Recombinant Antibody (CBWJC-2029) (CBMAB-C2645WJ)

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Target: CHD4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Dog, Pig, Horse
Clone: CBWJC-2029
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-CHD4 Recombinant Antibody (CBXC-2846) (CBMAB-C5387-CQ)

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Target: CHD4
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat, Dog, Pig, Horse
Clone: CBXC-2846
Application*: E, IF, IP, WB, P
Datasheet SDS

Mouse Anti-CHD4 Recombinant Antibody (CBFYC-1812) (CBMAB-C1874-FY)

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Target: CHD4
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat, Dog, Pig, Horse
Clone: CBFYC-1812
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-CHD4 Recombinant Antibody (5F1-A11-C9) (CBMAB-C7557-LY)

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Target: CHD4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5F1-A11-C9
Application*: WB, IP
Datasheet SDS

Mouse Anti-CHD4 Recombinant Antibody (4H4) (CBMAB-C7053-LY)

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Target: CHD4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4H4
Application*: E, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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