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CHD4

The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Full Name

Chromodomain Helicase DNA Binding Protein 4

Function

Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones.

Biological Process

ATP-dependent chromatin remodeling Source: UniProtKB
Regulation of signal transduction by p53 class mediator Source: Reactome
Regulation of transcription by RNA polymerase II Source: ProtInc

Cellular Location

Centrosome; Nucleus. Associates with centrosomes in interphase.

Involvement in disease

Sifrim-Hitz-Weiss syndrome (SIHIWES): An autosomal dominant syndrome characterized by mental retardation, variable congenital defects affecting cardiac, skeletal, and urogenital systems. Short stature, macrocephaly, hearing impairment, and facial dysmorphism are present in some patients.

Anti-CHD4 antibodies

Mouse Anti-CHD4 Recombinant Antibody (3F2/4) (CBMAB-C6027-LY)

SDS

Target: CHD4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Human

Clone: 3F2/4

Application*: WB, IP, E, P, F, CI, IC/IF

Rabbit Anti-CHD4 Recombinant Antibody (CBWJC-2638) (CBMAB-C3723WJ)

SDS

Target: CHD4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJC-2638

Application*: WB, F, IC

Rabbit Anti-CHD4 Recombinant Antibody (CBWJC-2637) (CBMAB-C3722WJ)

SDS

Target: CHD4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBWJC-2637

Application*: WB, F, IC

Rabbit Anti-CHD4 Recombinant Antibody (CBWJC-2636) (CBMAB-C3721WJ)

SDS

Target: CHD4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey, Hamster, Cattle, Pig, Guinea pig, Horse

Clone: CBWJC-2636

Application*: WB, IP

Rabbit Anti-CHD4 Recombinant Antibody (CBWJC-2635) (CBMAB-C3720WJ)

SDS

Target: CHD4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey, Hamster, Cattle, Pig, Guinea pig, Horse

Clone: CBWJC-2635

Application*: WB, IF, CI

Mouse Anti-CHD4 Recombinant Antibody (CBWJC-2029) (CBMAB-C2645WJ)

SDS

Target: CHD4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CBWJC-2029

Application*: WB, IP, F, E, IH, IC, IP, MC

Mouse Anti-CHD4 Recombinant Antibody (CBXC-2846) (CBMAB-C5387-CQ)

SDS

Target: CHD4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-2846

Application*: E, WB, IF

Mouse Anti-CHD4 Recombinant Antibody (CBFYC-1812) (CBMAB-C1874-FY)

SDS

Target: CHD4

Host: Mouse

Specificity: Human

Clone: CBFYC-1812

Application*: WB

Rabbit Anti-CHD4 Recombinant Antibody (EG663) (CBMAB-EN801-LY)

SDS

Target: CHD4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: EG663

Application*: IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:20000

Mouse Anti-CHD4 Recombinant Antibody (CAP499) (CBMAB-AP1495LY)

SDS

Target: CHD4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CAP499

Application*: WB

Mouse Anti-CHD4 Recombinant Antibody (2258) (CBMAB-AP1494LY)

SDS

Target: CHD4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2258

Application*: ELISA, IF, WB

Mouse Anti-CHD4 Recombinant Antibody (CAP498) (CBMAB-AP1493LY)

SDS

Target: CHD4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CAP498

Application*: WB

Mouse Anti-CHD4 Recombinant Antibody (CAP497) (CBMAB-AP1492LY)

SDS

Target: CHD4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CAP497

Application*: IP, WB

Mouse Anti-CHD4 Recombinant Antibody (CAP496) (CBMAB-AP1491LY)

SDS

Target: CHD4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CAP496

Application*: ELISA, IP, WB

Mouse Anti-CHD4 Recombinant Antibody (CF097) (CBMAB-FT375LY)

SDS

Target: CHD4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CF097

Application*: ELISA, WB

Mouse Anti-CHD4 Recombinant Antibody (CB472A) (CBMAB-CA472LY)

SDS

Target: CHD4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CB472A

Application*: ELISA, WB, IP

Rabbit Anti-CHD4 Recombinant Antibody (CBR066G) (CBMAB-BT034LY)

SDS

Target: CHD4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBR066G

Application*: WB, IP

Recombinant Mouse Anti-CHD4 Antibody (CBAb071) (CBMAB-Ab071-LY)

SDS

Target: CHD4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBAb071

Application*: WB

Rabbit Anti-CHD4 Recombinant Antibody (D4B7) (CBMAB-CP0292-LY)

SDS

Target: CHD4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey, Hamster, Cattle, Pig, Guinea pig, Horse

Clone: D4B7

Application*: WB, IF (IC), CI, CI-seq

Rabbit Anti-CHD4 Recombinant Antibody (D8B12) (CBMAB-CP0291-LY)

SDS

Target: CHD4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey, Hamster, Cattle, Pig, Guinea pig, Horse

Clone: D8B12

Application*: WB, IP

Mouse Anti-CHD4 Recombinant Antibody (13k32) (CBMAB-C2315-CN)

SDS

Target: CHD4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 13k32

Application*: WB

Mouse Anti-CHD4 Recombinant Antibody (5F1-A11-C9) (CBMAB-C7557-LY)

SDS

Target: CHD4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 5F1-A11-C9

Application*: WB, IP

Mouse Anti-CHD4 Recombinant Antibody (4H4) (CBMAB-C7053-LY)

SDS

Target: CHD4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4H4

Application*: E, P, WB

Mouse Anti-CHD4 Recombinant Antibody (15B129) (CBMAB-C0378-LY)

SDS

Target: CHD4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 15B129

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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