CHIT1
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]
Full Name
Chitinase 1
Function
Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.
Biological Process
Chitin catabolic process Source: UniProtKB
Immune response Source: UniProtKB
Neutrophil degranulation Source: Reactome
Polysaccharide catabolic process Source: UniProtKB-KW
Polysaccharide digestion Source: Reactome
Response to bacterium Source: ProtInc
Immune response Source: UniProtKB
Neutrophil degranulation Source: Reactome
Polysaccharide catabolic process Source: UniProtKB-KW
Polysaccharide digestion Source: Reactome
Response to bacterium Source: ProtInc
Cellular Location
Secreted; Lysosome. A small proportion is lysosomal.
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Anti-CHIT1 antibodies
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CompareTarget: CHIT1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EN815
Application*: WB
Target: CHIT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AO312
Application*: IP, N
Target: CHIT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2056
Application*: E, WB
Target: CHIT1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C0056
Application*: E, WB
Target: Chit1
Sensitivity: 0.0051 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: CHIT1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 22-464
Tag: His Tag
Target: CHIT1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-466
Tag: His Tag
Target: CHIT1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 22-466
Tag: His Tag
Target: CHIT1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT337
Application*: WB, E
Target: CHIT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4304
Application*: WB
Target: CHIT1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBXC-1172
Application*: E, WB
Target: CHIT1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYC-1838
Application*: WB, IP, IF, E
Target: CHIT1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1836
Application*: WB, IP, IF, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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