CHIT1

Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]
Full Name
Chitinase 1
Function
Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.
Biological Process
Chitin catabolic process Source: UniProtKB
Immune response Source: UniProtKB
Neutrophil degranulation Source: Reactome
Polysaccharide catabolic process Source: UniProtKB-KW
Polysaccharide digestion Source: Reactome
Response to bacterium Source: ProtInc
Cellular Location
Secreted; Lysosome. A small proportion is lysosomal.
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Anti-CHIT1 antibodies

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Rabbit Anti-CHIT1 Recombinant Antibody (EN815) (CBMAB-EN815-LY)

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Target: CHIT1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EN815
Application*: WB
Datasheet SDS

Mouse Anti-CHIT1 Recombinant Antibody (AO312) (CBMAB-AO312LY)

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Target: CHIT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AO312
Application*: IP, N
Functional Assay
Datasheet SDS

Mouse Anti-CHIT1 Recombinant Antibody (CBYY-C2056) (CBMAB-C3494-YY)

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Target: CHIT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2056
Application*: E, WB
Datasheet SDS

Mouse Anti-CHIT1 Recombinant Antibody (CBYY-C0056) (CBMAB-C0175-YY)

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Target: CHIT1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C0056
Application*: E, WB
Datasheet SDS

Mouse Anti-CHIT1 Recombinant Antibody (CBT337) (V2LY-0625-LY3586)

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Target: CHIT1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT337
Application*: WB, E
Datasheet SDS

Mouse Anti-CHIT1 Recombinant Antibody (CBT4304) (V2LY-0625-LY2260)

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Target: CHIT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4304
Application*: WB
Datasheet SDS

Mouse Anti-CHIT1 Recombinant Antibody (CBXC-1172) (CBMAB-C5346-CQ)

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Target: CHIT1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBXC-1172
Application*: E, WB
Datasheet SDS

Mouse Anti-CHIT1 Recombinant Antibody (CBFYC-1838) (CBMAB-C1902-FY)

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Target: CHIT1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYC-1838
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CHIT1 Recombinant Antibody (CBFYC-1836) (CBMAB-C1900-FY)

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Target: CHIT1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1836
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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