Mouse Anti-CHIT1 Recombinant Antibody (CBT4304) (V2LY-0625-LY2260)

Name: Mouse Anti-CHIT1 Recombinant Antibody (CBT4304)
SKU: V2LY-0625-LY2260
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-CHIT1 Recombinant Antibody (CBT4304) (V2LY-0625-LY2260) in WB

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBT4304

Antibody Isotype

IgG1

Application

Basic Information

Immunogen

Purified recombinant fragment of CHIT1 (aa22-137) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Preservative

Sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID

1118

UniProt ID

Q13231

Function

Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.

Biological Process

Chitin catabolic process Source: UniProtKB
Immune response Source: UniProtKB
Neutrophil degranulation Source: Reactome
Polysaccharide catabolic process Source: UniProtKB-KW
Polysaccharide digestion Source: Reactome
Response to bacterium Source: ProtInc

Cellular Location

Secreted; Lysosome. A small proportion is lysosomal.

More Infomation

References

Lee, J. H., Lee, C. M., Kim, M. O., Park, J. W., Kamle, S., Akosman, B., ... & Lee, C. G. (2021). Kasugamycin is a novel chitinase 1 inhibitor with strong antifibrotic effects on pulmonary fibrosis. bioRxiv.

Masrori, P., De Schaepdryver, M., Floeter, M. K., De Vocht, J., Lamaire, N., D'Hondt, A., ... & Van Damme, P. (2021). Prognostic relationship of neurofilaments, CHIT1, YKL-40 and MCP-1 in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery & Psychiatry.

Lee, C. M., He, C. H., Park, J. W., Lee, J. H., Kamle, S., Ma, B., ... & Lee, C. G. (2019). Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3. Life science alliance, 2(3).

Logue, E. C., Neff, C. P., Mack, D. G., Martin, A. K., Fiorillo, S., Lavelle, J., ... & Fontenot, A. P. (2019). Upregulation of chitinase 1 in alveolar macrophages of HIV-infected smokers. The Journal of Immunology, 202(5), 1363-1372.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Mouse Anti-CHIT1 Recombinant Antibody (CBXC-1172) (CAT#: CBMAB-C5346-CQ)

Mouse Anti-CHIT1 Recombinant Antibody (CBT337) (CAT#: V2LY-0625-LY3586)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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Second antibody and isotype control

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