Mouse Anti-CHIT1 Recombinant Antibody (CBXC-1172) (CBMAB-C5346-CQ)

Name: Mouse Anti-CHIT1 Recombinant Antibody (CBXC-1172)
SKU: CBMAB-C5346-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXC-1172

Application

ELISA, WB

Immunogen

Recombinant human Chitotriosidase/CHIT1, Ala22-Asn466.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG3

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Chitinase 1

Introduction

Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.

Entrez Gene ID

1118

UniProt ID

Q13231

Alternative Names

Chitinase 1; Chitinase 1 (Chitotriosidase); EC 3.2.1.14; Plasma Methylumbelliferyl Tetra-N-Acetylchitotetraoside Hydrolase; Chitotriosidase-1; Chitotriosidase;

Function

Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.

Biological Process

Chitin catabolic process Source: UniProtKB
Immune response Source: UniProtKB
Neutrophil degranulation Source: Reactome
Polysaccharide catabolic process Source: UniProtKB-KW
Polysaccharide digestion Source: Reactome
Response to bacterium Source: ProtInc

Cellular Location

Secreted; Lysosome. A small proportion is lysosomal.

Lee, J. H., Lee, C. M., Kim, M. O., Park, J. W., Kamle, S., Akosman, B., ... & Lee, C. G. (2021). Kasugamycin is a novel chitinase 1 inhibitor with strong antifibrotic effects on pulmonary fibrosis. bioRxiv.

Masrori, P., De Schaepdryver, M., Floeter, M. K., De Vocht, J., Lamaire, N., D'Hondt, A., ... & Van Damme, P. (2021). Prognostic relationship of neurofilaments, CHIT1, YKL-40 and MCP-1 in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery & Psychiatry.

Lee, C. M., He, C. H., Park, J. W., Lee, J. H., Kamle, S., Ma, B., ... & Lee, C. G. (2019). Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3. Life science alliance, 2(3).

Logue, E. C., Neff, C. P., Mack, D. G., Martin, A. K., Fiorillo, S., Lavelle, J., ... & Fontenot, A. P. (2019). Upregulation of chitinase 1 in alveolar macrophages of HIV-infected smokers. The Journal of Immunology, 202(5), 1363-1372.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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