CLEC4C

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Full Name
C-Type Lectin Domain Family 4 Member C
Function
Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448).

Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448).

Binds to serum IgG (PubMed:25995448).

Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed:11748283).

May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719).

May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283).
Biological Process
Adaptive immune response Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Neutrophil degranulation Source: Reactome
Stimulatory C-type lectin receptor signaling pathway Source: Reactome
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-21
Helical: 22-44
Extracellular: 45-213
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Anti-CLEC4C antibodies

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Human CLEC4C ELISA Kit (V2LY-0626-LY4452)

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Target: CLEC4C
Sensitivity: 0.054 ng/mL
Detection Range: 0.1-40 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Human Recombinant CLEC4C protein, ECD, hFc Tag (V2LY-0526-LY3223)

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Target: CLEC4C
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 45-213
Tag: hFc Tag
Datasheet SDS

Human Anti-CLEC4C Recombinant Antibody (
7B8) (V2LY-0725-LY1412)

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Target: CLEC4C
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: 7B8
Application*: E
Datasheet SDS

Mouse Anti-CLEC4C Recombinant Antibody (CBT4496) (V2LY-0625-LY1554)

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Target: CLEC4C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4496
Application*: F
Datasheet SDS

Human Anti-CLEC4C Recombinant Antibody (CBWJC-2040) (V2LY-1206-LY137)

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Target: CLEC4C
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2040
Application*: E, F
Datasheet SDS

Mouse Anti-CLEC4C Recombinant Antibody (CBFYC-0424) (V2LY-1206-LY136)

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Target: CLEC4C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey
Clone: CBFYC-0424
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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