CSF2
CSF2 (Colony Stimulating Factor 2) is a Protein Coding gene. Diseases associated with CSF2 include Mucositis and Cyclic Neutropenia. Among its related pathways are RET signaling and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and granulocyte macrophage colony-stimulating factor receptor binding.
Full Name
Colony Stimulating Factor 2
Function
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
Biological Process
Cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: CAFA
Cellular response to lipopolysaccharide Source: Ensembl
Cytokine-mediated signaling pathway Source: Reactome
Dendritic cell differentiation Source: DFLAT
Embryonic placenta development Source: Ensembl
Epithelial fluid transport Source: Ensembl
Histamine secretion Source: Ensembl
Immune response Source: InterPro
Macrophage activation Source: Ensembl
Macrophage differentiation Source: ARUK-UCL
MAPK cascade Source: Reactome
Monocyte differentiation Source: Ensembl
Myeloid cell differentiation Source: GO_Central
Myeloid dendritic cell differentiation Source: UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Neutrophil differentiation Source: Ensembl
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of interleukin-23 production Source: BHF-UCL
Positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Positive regulation of podosome assembly Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
Regulation of circadian sleep/wake cycle, sleep Source: Ensembl
Regulation of myeloid cell differentiation Source: Reactome
Response to fluid shear stress Source: Ensembl
Response to silicon dioxide Source: Ensembl
Cellular response to lipopolysaccharide Source: Ensembl
Cytokine-mediated signaling pathway Source: Reactome
Dendritic cell differentiation Source: DFLAT
Embryonic placenta development Source: Ensembl
Epithelial fluid transport Source: Ensembl
Histamine secretion Source: Ensembl
Immune response Source: InterPro
Macrophage activation Source: Ensembl
Macrophage differentiation Source: ARUK-UCL
MAPK cascade Source: Reactome
Monocyte differentiation Source: Ensembl
Myeloid cell differentiation Source: GO_Central
Myeloid dendritic cell differentiation Source: UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Neutrophil differentiation Source: Ensembl
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of interleukin-23 production Source: BHF-UCL
Positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Positive regulation of podosome assembly Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
Regulation of circadian sleep/wake cycle, sleep Source: Ensembl
Regulation of myeloid cell differentiation Source: Reactome
Response to fluid shear stress Source: Ensembl
Response to silicon dioxide Source: Ensembl
Cellular Location
Secreted
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Anti-CSF2 antibodies
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CompareTarget: CSF2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 10B2340
Application*: WB, E
Target: CSF2
Sensitivity: 0.0054 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Pig
Assay Type: Sandwich
Reactivity: Pig
Target: CSF2
Sensitivity: 0.004 ng/mL
Detection Range: 0.007-1.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Cattle
Assay Type: Sandwich
Reactivity: Cattle
Target: Csf2
Sensitivity: 0.0014 ng/mL
Detection Range: 0.003-0.9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: CSF2
Sensitivity: 0.00064 ng/mL
Detection Range: 0.001-0.4 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Sheep
Assay Type: Sandwich
Reactivity: Sheep
Target: CSF2
Sensitivity: 0.0015 ng/mL
Detection Range: 0.003-0.6 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Dog
Assay Type: Sandwich
Reactivity: Dog
Target: CSF2
Sensitivity: 0.52 ng/mL
Detection Range: 1-350 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: CSF2
Sensitivity: 0.0021 ng/mL
Detection Range: 0.005-1 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Cattle
Assay Type: Sandwich
Reactivity: Cattle
Target: Csf2
Sensitivity: 0.00051 ng/mL
Detection Range: 0.001-0.3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: CSF2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-144
Target: CSF2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-144
Target: CSF2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 18-144
Tag: His Tag
Target: CSF2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 18-144
Tag: hFc Tag
Target: CSF2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 18-141
Tag: His Tag
Target: CSF2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 18-141
Tag: hFc Tag
Target: CSF2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-141
Target: CSF2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-144
Target: CSF2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-144
Target: CSF2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-144
Target: CSF2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 18-144
Tag: His Tag
Target: CSF2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 18-144
Tag: hFc Tag
Target: CSF2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT627
Application*: WB, E
Target: CSF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2484
Application*: WB
Target: CSF2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-2280
Application*: E, WB
Target: CSF2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-2279
Application*: E
Target: CSF2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-2278
Application*: E, WB
Target: CSF2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-3389
Application*: N, E
Target: CSF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-372
Application*: IP, WB
Target: CSF2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-367
Application*: WB, IP, IF, P
Target: CSF2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-365
Application*: E
Target: CSF2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-364
Application*: WB, IP, IF, E
Target: CSF2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0103
Application*: E, F, IF, in vivo
Target: CSF2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-2282
Application*: E, WB
Target: CSF2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2G9
Application*: E, WB
Target: CSF2
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-369
Application*: E, F
Target: CSF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-368
Application*: WB, IP, IF
Target: CSF2
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Mouse, Rat
Clone: CBLG1-363
Application*: WB, IP, IF, E
Target: CSF2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 22E9
Application*: F, N
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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