CSF3
CSF3 (Colony Stimulating Factor 3) is a Protein Coding gene. Diseases associated with CSF3 include Neutropenia and Severe Congenital Neutropenia. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include enzyme binding and growth factor activity.
Full Name
Colony Stimulating Factor 3
Function
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
Biological Process
Cellular response to cytokine stimulus Source: BHF-UCL
Cellular response to lipopolysaccharide Source: Ensembl
Cytokine-mediated signaling pathway Source: Reactome
Granulocyte differentiation Source: UniProtKB
Immune response Source: InterPro
Multicellular organism development Source: ProtInc
Negative regulation of neuron death Source: Ensembl
Positive regulation of actin cytoskeleton reorganization Source: BHF-UCL
Positive regulation of actin filament polymerization Source: BHF-UCL
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
Positive regulation of myeloid cell differentiation Source: GO_Central
Positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
Positive regulation of protein binding Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Response to ethanol Source: Ensembl
Cellular response to lipopolysaccharide Source: Ensembl
Cytokine-mediated signaling pathway Source: Reactome
Granulocyte differentiation Source: UniProtKB
Immune response Source: InterPro
Multicellular organism development Source: ProtInc
Negative regulation of neuron death Source: Ensembl
Positive regulation of actin cytoskeleton reorganization Source: BHF-UCL
Positive regulation of actin filament polymerization Source: BHF-UCL
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
Positive regulation of myeloid cell differentiation Source: GO_Central
Positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
Positive regulation of protein binding Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Response to ethanol Source: Ensembl
Cellular Location
Secreted
PTM
O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells).
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Anti-CSF3 antibodies
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CompareTarget: CSF3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-008
Application*: E
Target: CSF3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: G1451
Application*: E, WB
Target: CSF3
Sensitivity: 0.0025 ng/mL
Detection Range: 0.005-1 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Pig
Assay Type: Sandwich
Reactivity: Pig
Target: CSF3
Sensitivity: 0.004 ng/mL
Detection Range: 0.007-1.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Dog
Assay Type: Sandwich
Reactivity: Dog
Target: CSF3
Sensitivity: 0.053 ng/mL
Detection Range: 1-40 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: CSF3
Sensitivity: 0.0053 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Cattle
Assay Type: Sandwich
Reactivity: Cattle
Target: Csf3
Sensitivity: 0.0015 ng/mL
Detection Range: 0.003-0.9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: CSF3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-208
Target: CSF3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 30-204
Tag: hFc Tag
Target: CSF3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-204
Target: CSF3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-204
Target: CSF3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2691
Application*: IC, F
Target: CSF3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4377
Application*: IH, IC
Target: CSF3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2486
Application*: E
Target: CSF3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2C5
Application*: E, IP
Target: CSF3
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 10C427
Application*: E, WB, N
Target: CSF3
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBLG1-009
Application*: E
Target: CSF3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0111
Application*: E, WB
Target: CSF3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0108
Application*: E, WB, N
Target: CSF3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-0107
Application*: E, WB
Target: CSF3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2948
Application*: E
Target: CSF3
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3A5
Application*: E
Target: CSF3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-2862
Application*: E, WB
Target: CSF3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0110
Application*: E
Target: CSF3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0109
Application*: WB, IP, IF, P
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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