CSNK1E

The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
Full Name
CSNK1E
Function
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
Biological Process
Canonical Wnt signaling pathway Source: WormBase
Ciliary basal body-plasma membrane docking Source: Reactome
Circadian regulation of gene expression Source: UniProtKB
DNA repair Source: ProtInc
Endocytosis Source: GO_Central
G2/M transition of mitotic cell cycle Source: Reactome
Negative regulation of protein binding Source: ParkinsonsUK-UCL
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of canonical Wnt signaling pathway Source: GO_Central
Positive regulation of non-canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
Protein phosphorylation Source: UniProtKB
Regulation of cellular protein localization Source: ParkinsonsUK-UCL
Regulation of circadian rhythm Source: UniProtKB
Regulation of G2/M transition of mitotic cell cycle Source: Reactome
Signal transduction Source: ProtInc
Wnt signaling pathway Source: GO_Central
Cellular Location
Cytoplasm; Nucleus
PTM
Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1.
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Anti-CSNK1E antibodies

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Mouse Anti-CSNK1E Recombinant Antibody (5D4) (CBMAB-C7461-LY)

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Target: CSNK1E
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 5D4
Application*: IH, WB
Datasheet SDS

Mouse Anti-CSNK1E Recombinant Antibody (5C9) (CBMAB-C7439-LY)

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Target: CSNK1E
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 5C9
Application*: WB
Datasheet SDS

Rabbit Anti-CSNK1E Recombinant Antibody (CBYY-C2173) (V2LY-0125-LY20)

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Target: CSNK1E
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYY-C2173
Application*: WB
Datasheet SDS

Mouse Anti-CSNK1E Recombinant Antibody (CBYY-C2172) (V2LY-0125-LY19)

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Target: CSNK1E
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2172
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CSNK1E Recombinant Antibody (CBFYC-2297) (V2LY-0125-LY18)

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Target: CSNK1E
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Chicken, Dog, Mouse, Rat, Pig, Horse
Clone: CBFYC-2297
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CSNK1E Recombinant Antibody (CBFYC-2296) (V2LY-0125-LY17)

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Target: CSNK1E
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Chicken, Dog, Mouse, Rat, Pig, Horse
Clone: CBFYC-2296
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CSNK1E Recombinant Antibody (5H10) (V2LY-0125-LY16)

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Target: CSNK1E
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 5H10
Application*: IH, WB
Datasheet SDS

Mouse Anti-CSNK1E Recombinant Antibody (2E1) (V2LY-0125-LY13)

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Target: CSNK1E
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E1
Application*: E, IF
Datasheet SDS

Mouse Anti-CSNK1E Recombinant Antibody (2B3) (V2LY-0125-LY12)

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Target: CSNK1E
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 2B3
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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