DAAM1

Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined. [provided by RefSeq]

Full Name

dishevelled associated activator of morphogenesis 1

Function

Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208).

Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity).

Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity).

Biological Process

Actin cytoskeleton organization Source: InterPro
Wnt signaling pathway, planar cell polarity pathway Source: Reactome

Cellular Location

Cilium basal body; Cytoplasm. Perinuclear.