DACH1

This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Full Name

Dachshund Family Transcription Factor 1

Function

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity).

Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).

Biological Process

Cell population proliferation Source: Ensembl
Development of primary female sexual characteristics Source: Ensembl
Negative regulation of cell migration Source: BHF-UCL
Negative regulation of cell proliferation involved in contact inhibition Source: Ensembl
Negative regulation of DNA biosynthetic process Source: CACAO
Negative regulation of fibroblast proliferation Source: Ensembl
Negative regulation of transcription, DNA-templated Source: CACAO
Negative regulation of transcription by competitive promoter binding Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of nuclear cell cycle DNA replication Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Respiratory gaseous exchange by respiratory system Source: Ensembl
Suckling behavior Source: Ensembl

Cellular Location

Nucleus