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DCK

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
Full Name
deoxycytidine kinase
Function
Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:1996353, PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:20614893).

Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445).
Biological Process
Purine-containing compound salvage Source: Reactome
Pyrimidine nucleoside salvage Source: Reactome
Pyrimidine nucleotide metabolic process Source: UniProtKB
Cellular Location
Nucleus
PTM
Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.

Anti-DCK antibodies

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Mouse Anti-DCK Recombinant Antibody (16G6) (CBMAB-D0343-YC)

Datasheet SDS
Target: DCK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 16G6
Application*: F, WB

Mouse Anti-DCK Recombinant Antibody (1G6) (CBMAB-D0344-YC)

Datasheet SDS
Target: DCK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1G6
Application*: E

Mouse Anti-DCK Recombinant Antibody (2243C2) (CBMAB-D0345-YC)

Datasheet SDS
Target: DCK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2243C2
Application*: DB

Mouse Anti-DCK Recombinant Antibody (3F5) (CBMAB-D0348-YC)

Datasheet SDS
Target: DCK
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Monkey
Clone: 3F5
Application*: WB, F, C, IC, IF, P

Mouse Anti-DCK Recombinant Antibody (4H3) (CBMAB-D0349-YC)

Datasheet SDS
Target: DCK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4H3
Application*: E, WB

Mouse Anti-DCK Recombinant Antibody (3E4) (CBMAB-A2105-LY)

Datasheet SDS
Target: DCK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E4
Application*: SE, E

Mouse Anti-DCK Recombinant Antibody (15E12) (CBMAB-D0341-YC)

Datasheet SDS
Target: DCK
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 15E12
Application*: F, IF, WB

Mouse Anti-DCK Recombinant Antibody (2F10) (CBMAB-D0346-YC)

Datasheet SDS
Target: DCK
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2F10
Application*: E, IC, IF, WB

Mouse Anti-DCK Recombinant Antibody (CBYCD-179) (CBMAB-D0350-YC)

Datasheet SDS
Target: DCK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCD-179
Application*: WB

Mouse Anti-DCK Recombinant Antibody (CBYCD-180) (CBMAB-D0351-YC)

Datasheet SDS
Target: DCK
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBYCD-180
Application*: IC, IF, P, IP, WB

Mouse Anti-DCK Recombinant Antibody (1D12) (CBMAB-D0352-YC)

Datasheet SDS
Target: DCK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D12
Application*: E, IF, WB

Mouse Anti-DCK Recombinant Antibody (1E7) (CBMAB-D0354-YC)

Datasheet SDS
Target: DCK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E7
Application*: E

Mouse Anti-DCK Recombinant Antibody (3G10) (CBMAB-BR153LY)

Datasheet SDS
Target: DCK
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3G10
Application*: FC, IHC-P, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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