DCST1

DCST1 is a protein with a domain similar to one found in dendritic cells which play a key role in antigen processing and display for immune responses.

Full Name

DC-STAMP domain containing 1

Function

E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.

Biological Process

Innate immune response Source: UniProtKB-KW
Negative regulation of type I interferon-mediated signaling pathway Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: UniProtKB

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-48
Helical: 49-69
Extracellular: 70-79
Helical: 80-100
Cytoplasmic: 101-115
Helical: 116-136
Extracellular: 137-372
Helical: 373-393
Cytoplasmic: 394-463
Helical: 464-484
Extracellular: 485-553
Helical: 554-574
Cytoplasmic: 575-706

Anti-DCST1 antibodies

Mouse Anti-DCST1 Recombinant Antibody (2C12) (CBMAB-D0396-YC)

Datasheet

SDS

Target: DCST1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2C12

Application*: E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)