DLX2

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq]
Full Name
distal-less homeobox 2
Function
Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.
Biological Process
Brain development Source: ProtInc
Branching morphogenesis of a nerve Source: Ensembl
Cartilage development Source: Ensembl
Cell differentiation Source: GO_Central
Cerebral cortex GABAergic interneuron fate commitment Source: Ensembl
Embryonic cranial skeleton morphogenesis Source: Ensembl
Forebrain neuron differentiation Source: Ensembl
Hippocampus development Source: Ensembl
Negative regulation of Notch signaling pathway Source: Ensembl
Negative regulation of oligodendrocyte differentiation Source: Ensembl
Negative regulation of photoreceptor cell differentiation Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Odontogenesis of dentin-containing tooth Source: Ensembl
Olfactory bulb development Source: Ensembl
Positive regulation of amacrine cell differentiation Source: UniProtKB
Positive regulation of cell differentiation Source: UniProtKB
Proximal/distal pattern formation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Subpallium development Source: Ensembl
Cellular Location
Nucleus
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Anti-DLX2 antibodies

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Mouse Anti-DLX2 Recombinant Antibody (D1130) (CBMAB-A2270-LY)

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Target: DLX2
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat, Chicken
Clone: D1130
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-DLX2 Recombinant Antibody (4B9) (V2LY-0425-LY509)

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Target: DLX2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4B9
Application*: E, WB
Datasheet SDS

Mouse Anti-DLX2 Recombinant Antibody (D1129) (V2LY-0425-LY514)

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Target: DLX2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: D1129
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-DLX2 Recombinant Antibody (2H2) (V2LY-0425-LY512)

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Target: DLX2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 2H2
Application*: E, P, WB
Datasheet SDS

Mouse Anti-DLX2 Recombinant Antibody (2B12) (V2LY-0425-LY511)

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Target: DLX2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 2B12
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-DLX2 Recombinant Antibody (1E9) (V2LY-0425-LY510)

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Target: DLX2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 1E9
Application*: E, WB
Datasheet SDS

Mouse Anti-DLX2 Recombinant Antibody (2H3) (CBMAB-D1127-YC)

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Target: DLX2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 2H3
Application*: E, IF, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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