DOT1L

The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
Full Name
DOT1 Like Histone Lysine Methyltransferase
Function
Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582).

Binds to DNA (PubMed:12628190).
Biological Process
Chromatin silencing at telomere Source: GO_Central
DNA damage checkpoint signaling Source: GO_Central
DNA repair Source: GO_Central
Gene expression Source: Ensembl
Histone H3-K79 methylation Source: MGI
Positive regulation of cell population proliferation Source: MGI
Positive regulation of transcription by RNA polymerase II Source: MGI
Regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
Regulation of transcription regulatory region DNA binding Source: UniProtKB
Telomere organization Source: BHF-UCL
Cellular Location
Nucleus
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Anti-DOT1L antibodies

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Mouse Anti-DOT1L Recombinant Antibody (6E7) (CBMAB-D1529-YC)

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Target: DOT1L
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 6E7
Application*: E, IF, IP
Datasheet SDS

Rabbit Anti-DOT1L Recombinant Antibody (
3B6) (V2LY-0725-LY1089)

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Target: DOT1L
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 3B6
Application*: E, WB
Datasheet SDS

Mouse Anti-DOT1L Recombinant Antibody (K0314) (V2LY-0425-LY807)

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Target: DOT1L
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: K0314
Application*: P, IP
Datasheet SDS

Mouse Anti-DOT1L Recombinant Antibody (CBYCD-382) (V2LY-0425-LY805)

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Target: DOT1L
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBYCD-382
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-DOT1L Recombinant Antibody (CP0493) (CBMAB-CP0493-LY)

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Target: DOT1L
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CP0493
Application*: WB, P
Datasheet SDS

Mouse Anti-DOT1L Recombinant Antibody (8B2) (CBMAB-D1535-YC)

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Target: DOT1L
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 8B2
Application*: E, WB
Datasheet SDS

Mouse Anti-DOT1L Recombinant Antibody (6E8) (CBMAB-D1532-YC)

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Target: DOT1L
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 6E8
Application*: E, IF, IP
Datasheet SDS

Mouse Anti-DOT1L Recombinant Antibody (1D8) (CBMAB-D1522-YC)

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Target: DOT1L
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 1D8
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DOT1L Recombinant Antibody (11H2) (CBMAB-D1521-YC)

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Target: DOT1L
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 11H2
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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