DPF1

DPF1 (Double PHD Fingers 1) is a protein coding gene. Among its related pathways are Gastric cancer. It has proved that the protein has nucleic acid binding. And a paralog is DPF2.

Full Name

DPF1

Function

May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Biological Process

Apoptotic process Source: ProtInc
Negative regulation of transcription, DNA-templated Source: GO_Central
Nervous system development Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Cytoplasm; Nucleus