EDA2R

EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Multiple alternatively spliced transcript variants have been found for this gene, but some variants lack sufficient support. [provided by RefSeq]
Full Name
EDA2R
Research Area
Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.
Biological Process
Ectodermal cell differentiation Source: BHF-UCL
Epidermis development Source: UniProtKB
Intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
Positive regulation of JNK cascade Source: HGNC-UCL
Positive regulation of NF-kappaB transcription factor activity Source: HGNC-UCL
Cellular Location
Membrane
Topology
Extracellular: 1-138
Helical: 139-159
Cytoplasmic: 160-297
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Anti-EDA2R antibodies

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Mouse Anti-EDA2R Recombinant Antibody (2L23) (CBMAB-X0011-YC)

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Target: EDA2R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2L23
Application*: WB, E
Datasheet SDS

Mouse Anti-EDA2R Recombinant Antibody (CBFYE-0427) (CBMAB-E0745-FY)

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Target: EDA2R
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYE-0427
Application*: E, WB
Datasheet SDS

Mouse Anti-EDA2R Recombinant Antibody (CBFYE-0021) (CBMAB-E0046-FY)

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Target: EDA2R
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-0021
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-EDA2R Recombinant Antibody (3C1) (CBMAB-X0014-YC)

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Target: EDA2R
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 3C1
Application*: E, WB
Datasheet SDS

Rabbit Anti-EDA2R Recombinant Antibody (72) (CBMAB-X0013-YC)

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Target: EDA2R
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 72
Application*: E
Datasheet SDS

Mouse Anti-EDA2R Recombinant Antibody (53) (CBMAB-X0012-YC)

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Target: EDA2R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 53
Application*: E
Datasheet SDS

Rat Recombinant EDA2R protein, His Tag (V2LY-0526-LY9343)

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Target: EDA2R
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 2-137
Tag: His Tag
Datasheet SDS

Rat Recombinant EDA2R protein, hFc Tag (V2LY-0526-LY9342)

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Target: EDA2R
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 2-137
Tag: hFc Tag
Datasheet SDS

Mouse Recombinant EDA2R protein, hFc Tag (V2LY-0526-LY8218)

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Target: EDA2R
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-138
Tag: hFc Tag
Datasheet SDS

Mouse Recombinant EDA2R protein, ECD, His Tag (V2LY-0526-LY8217)

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Target: EDA2R
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-138
Tag: His Tag
Datasheet SDS

Human Recombinant EDA2R protein, His Tag (V2LY-0526-LY3684)

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Target: EDA2R
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-138
Tag: His Tag
Datasheet SDS

Human Recombinant EDA2R protein, hFc Tag (V2LY-0526-LY3683)

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Target: EDA2R
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-136
Tag: hFc Tag
Datasheet SDS

Cynomolgus Recombinant EDA2R protein, hFc Tag (V2LY-0526-LY1492)

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Target: EDA2R
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-136
Tag: hFc Tag
Datasheet SDS

Cynomolgus Recombinant EDA2R protein, ECD, His Tag (V2LY-0526-LY1491)

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Target: EDA2R
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-136
Tag: His Tag
Datasheet SDS

Mouse Anti-EDA2R Recombinant Antibody (CBT3178) (V2LY-0625-LY1204)

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Target: EDA2R
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3178
Application*: F
Datasheet SDS

EDA2R Matched Antibody Pair (362) (APMAB-362LY)

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Target: EDA2R
Specificity: Human
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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