Mouse Anti-EDA2R Recombinant Antibody (2L23) (CBMAB-X0011-YC)

Name: Mouse Anti-EDA2R Recombinant Antibody (2L23)
SKU: CBMAB-X0011-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2L23

Application

WB, ELISA

Immunogen

Recombinant human EDA2R (Met1-Glu136).

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	2-8 µg/ml
WB	1 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

Trehalose & PBS

Preservative

None

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

EDA2R

Introduction

EDA2R is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. EDA2R binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. EDA2R mediates the activation of the NF-kappa-B and JNK pathways and activation seems to be mediated by binding to TRAF3 and TRAF6.

Entrez Gene ID

60401

UniProt ID

Q9HAV5

Alternative Names

XEDAR; EDAA2R; EDA-A2R; TNFRSF27

Research Area

Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.

Biological Process

Ectodermal cell differentiation Source: BHF-UCL
Epidermis development Source: UniProtKB
Intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
Positive regulation of JNK cascade Source: HGNC-UCL
Positive regulation of NF-kappaB transcription factor activity Source: HGNC-UCL

Cellular Location

Membrane

Topology

Extracellular: 1-138
Helical: 139-159
Cytoplasmic: 160-297

Jia, N., Jia, Y., Yang, F., & Du, W. (2022). Knockdown of EDA2R alleviates hyperoxia-induced lung epithelial cell injury by inhibiting NF-κB pathway. Allergologia et Immunopathologia, 50(5), 84-90.

Song, L., Chang, R., Sun, X., Lu, L., Gao, H., Lu, H., ... & Zhan, L. (2021). Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice. Communications biology, 4(1), 1-14.

Kwack, M. H., Jun, M. S., Sung, Y. K., Kim, J. C., & Kim, M. K. (2020). Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor. Biochemical and Biophysical Research Communications, 529(3), 766-772.

Lan, X., Kumar, V., Jha, A., Aslam, R., Wang, H., Chen, K., ... & Singhal, P. C. (2020). EDA2R mediates podocyte injury in high glucose milieu. Biochimie, 174, 74-83.

Kwack, M. H., Kim, J. C., & Kim, M. K. (2019). Ectodysplasin-A2 induces apoptosis in cultured human hair follicle cells and promotes regression of hair follicles in mice. Biochemical and Biophysical Research Communications, 520(2), 428-433.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

EDA2R Matched Antibody Pair (362) (CAT#: APMAB-362LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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