Human Recombinant EDA2R protein, His Tag (V2LY-0526-LY3684)

Name: Human Recombinant EDA2R protein, His Tag
SKU: V2LY-0526-LY3684
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant EDA2R protein, His Tag consist of Amino Acid: 1-138 and predicts a molecular mass of 16.7 kDa.

Molecule Mass

16.7 kDa

Sequence

Amino Acid: 1-138

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

EDA2R

Research Area

Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.

Biological Process

Ectodermal cell differentiation Source: BHF-UCL
Epidermis development Source: UniProtKB
Intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
Positive regulation of JNK cascade Source: HGNC-UCL
Positive regulation of NF-kappaB transcription factor activity Source: HGNC-UCL

Cellular Location

Membrane

Topology

Extracellular: 1-138
Helical: 139-159
Cytoplasmic: 160-297

Jia, N., Jia, Y., Yang, F., & Du, W. (2022). Knockdown of EDA2R alleviates hyperoxia-induced lung epithelial cell injury by inhibiting NF-κB pathway. Allergologia et Immunopathologia, 50(5), 84-90.

Song, L., Chang, R., Sun, X., Lu, L., Gao, H., Lu, H., ... & Zhan, L. (2021). Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice. Communications biology, 4(1), 1-14.

Kwack, M. H., Jun, M. S., Sung, Y. K., Kim, J. C., & Kim, M. K. (2020). Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor. Biochemical and Biophysical Research Communications, 529(3), 766-772.

Lan, X., Kumar, V., Jha, A., Aslam, R., Wang, H., Chen, K., ... & Singhal, P. C. (2020). EDA2R mediates podocyte injury in high glucose milieu. Biochimie, 174, 74-83.

Kwack, M. H., Kim, J. C., & Kim, M. K. (2019). Ectodysplasin-A2 induces apoptosis in cultured human hair follicle cells and promotes regression of hair follicles in mice. Biochemical and Biophysical Research Communications, 520(2), 428-433.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

EDA2R Matched Antibody Pair (362) (CAT#: APMAB-362LY)

Cynomolgus Recombinant EDA2R protein, ECD, His Tag (CAT#: V2LY-0526-LY1491)

Cynomolgus Recombinant EDA2R protein, hFc Tag (CAT#: V2LY-0526-LY1492)

Human Recombinant EDA2R protein, hFc Tag (CAT#: V2LY-0526-LY3683)

Mouse Recombinant EDA2R protein, ECD, His Tag (CAT#: V2LY-0526-LY8217)

Mouse Recombinant EDA2R protein, hFc Tag (CAT#: V2LY-0526-LY8218)

Rat Recombinant EDA2R protein, hFc Tag (CAT#: V2LY-0526-LY9342)

Rat Recombinant EDA2R protein, His Tag (CAT#: V2LY-0526-LY9343)

Antibody Pairs

EDA2R Matched Antibody Pair (362) (CAT#: APMAB-362LY)

Related Products

Rat Recombinant EDA2R protein, hFc Tag (CAT#: V2LY-0526-LY9342)

Mouse Anti-EDA2R Recombinant Antibody (CBT3178) (CAT#: V2LY-0625-LY1204)

Cynomolgus Recombinant EDA2R protein, hFc Tag (CAT#: V2LY-0526-LY1492)

Mouse Anti-EDA2R Recombinant Antibody (CBFYE-0021) (CAT#: CBMAB-E0046-FY)

Rabbit Anti-EDA2R Recombinant Antibody (72) (CAT#: CBMAB-X0013-YC)

Mouse Recombinant EDA2R protein, ECD, His Tag (CAT#: V2LY-0526-LY8217)

Mouse Anti-EDA2R Recombinant Antibody (CBFYE-0427) (CAT#: CBMAB-E0745-FY)

Mouse Recombinant EDA2R protein, hFc Tag (CAT#: V2LY-0526-LY8218)

Mouse Anti-EDA2R Recombinant Antibody (2L23) (CAT#: CBMAB-X0011-YC)

EDA2R Matched Antibody Pair (362) (CAT#: APMAB-362LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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