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Mouse Anti-EDA2R (AA 2-135) Recombinant Antibody (CBFYE-0427) (CBMAB-E0745-FY)

This product is mouse antibody that recognizes EDA2R. The antibody CBFYE-0427 can be used for immunoassay techniques such as: ELISA, WB.
See all EDA2R antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0427
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
EDA2R partial recombinant protein with GST tag. Immunogen sequence: DCQENEYWDQ WGRCVTCQRC GPGQELSKDC GYGEGGDAYC TACPPRRYKS SWGHHRCQSC ITCAVINRVQ KVNCTATSNA VCGDCLPRFY RKTRIGGLQD QECIPCTKQT PTSEVQCAFQ LSLVEADAPT VPPQ
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 2-135

Target

Full Name
EDA2R
Introduction
The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth.
Entrez Gene ID
60401
UniProt ID
Q9HAV5
Alternative Names
XEDAR; EDAA2R; EDA-A2R; TNFRSF27
Research Area
Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.
Biological Process
Ectodermal cell differentiation Source: BHF-UCL
Epidermis development Source: UniProtKB
Intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
Positive regulation of JNK cascade Source: HGNC-UCL
Positive regulation of NF-kappaB transcription factor activity Source: HGNC-UCL
Cellular Location
Membrane
Topology
Extracellular: 1-138
Helical: 139-159
Cytoplasmic: 160-297
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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