Sign in or Register   Sign in or Register
  |  

Mouse Anti-EDA2R Recombinant Antibody (3C1) (CBMAB-X0014-YC)

Provided herein is a Mouse monoclonal antibody against Human EDA2R. The antibody, clone 3C1, can be used for immunoassay techniques, such as ELISA, WB.
See all EDA2R antibodies
Published Data
Fig.1 Representative examples of western blots using lung homogenate from Nrf2+/+ and Nrf2−/− neonatal mice. Increased protein expression of p21 and Xedar found in lung from Nrf2 +/+ and Nrf2−/− neonatal mice exposed to 3 days of hyperoxia.
...View More
Fig.2 Representative examples of western blots using lung homogenate from Nrf2+/+ and Nrf2-/-neonatal mice.
...View More

Summary

Host Animal
Mouse
Specificity
Human
Clone
3C1
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein corresponding to a portion of amino acids within aa1-111 of human XEDAR
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
EDA2R
Introduction
EDA2R is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. EDA2R binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. EDA2R mediates the activation of the NF-kappa-B and JNK pathways and activation seems to be mediated by binding to TRAF3 and TRAF6.
Entrez Gene ID
60401
UniProt ID
Q9HAV5
Alternative Names
XEDAR; EDAA2R; EDA-A2R; TNFRSF27
Research Area
Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.
Biological Process
Ectodermal cell differentiation Source: BHF-UCL
Epidermis development Source: UniProtKB
Intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
Positive regulation of JNK cascade Source: HGNC-UCL
Positive regulation of NF-kappaB transcription factor activity Source: HGNC-UCL
Cellular Location
Membrane
Topology
Extracellular: 1-138
Helical: 139-159
Cytoplasmic: 160-297
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-EDA2R Recombinant Antibody (3C1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare