EID2

EID2 (EP300 Interacting Inhibitor Of Differentiation 2) is a Protein Coding gene. Among its related pathways are TGF-beta Signaling Pathway (WikiPathways). Gene Ontology (GO) annotations related to this gene include SMAD binding. An important paralog of this gene is EID2B.

Full Name

EP300 Interacting Inhibitor Of Differentiation 2

Research Area

Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.

Biological Process

Cell differentiation Source: UniProtKB-KW
Muscle organ development Source: UniProtKB-KW
Negative regulation of transcription, DNA-templated Source: HGNC-UCL
Negative regulation of transcription by RNA polymerase II Source: InterPro
Negative regulation of transforming growth factor beta receptor signaling pathway Source: HGNC-UCL
Regulation of cell population proliferation Source: HGNC-UCL
Regulation of transforming growth factor beta receptor signaling pathway Source: HGNC-UCL
SMAD protein complex assembly Source: HGNC-UCL
Transforming growth factor beta receptor complex assembly Source: HGNC-UCL

Cellular Location

Nucleus