EIF3K

The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]).[supplied by OMIM, Mar 2008]
Full Name
Eukaryotic Translation Initiation Factor 3 Subunit K
Research Area
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815).

The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632).

The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Biological Process
Formation of cytoplasmic translation initiation complex Source: UniProtKB-UniRule
Regulation of translational initiation Source: InterPro
Translational initiation Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm
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Anti-EIF3K antibodies

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Mouse Anti-EIF3K Recombinant Antibody (CBFYE-0690) (V2LY-0425-LY1705)

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Target: EIF3K
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Pig
Clone: CBFYE-0690
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-EIF3K Recombinant Antibody (CBFYE-0689) (V2LY-0425-LY1704)

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Target: EIF3K
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBFYE-0689
Application*: WB, IP
Datasheet SDS

Mouse Anti-EIF3K Recombinant Antibody (E1111) (V2LY-0425-LY1703)

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Target: EIF3K
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: E1111
Application*: IF
Datasheet SDS

Mouse Anti-EIF3K Recombinant Antibody (CBFYE-0690) (CBMAB-E1112-FY)

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Target: EIF3K
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0690
Application*: IF
Datasheet SDS

Mouse Anti-EIF3K Recombinant Antibody (CBFYE-0689) (CBMAB-E1110-FY)

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Target: EIF3K
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYE-0689
Application*: WB
Datasheet SDS

Mouse Anti-EIF3K Recombinant Antibody (2313C2a) (CBMAB-E1111-FY)

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Target: EIF3K
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2313C2a
Application*: DB, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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