ENPEP
ENPEP (Glutamyl Aminopeptidase) is a Protein Coding gene. Diseases associated with ENPEP include Neurogenic Hypertension and Gestational Choriocarcinoma. Among its related pathways are Peptide hormone metabolism and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include peptidase activity and aminopeptidase activity. An important paralog of this gene is ANPEP.
Full Name
Glutamyl Aminopeptidase
Research Area
Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.
Biological Process
Angiogenesis Source: UniProtKB
Angiotensin maturation Source: UniProtKB
Cell-cell signaling Source: UniProtKB
Cell migration Source: MGI
Cell population proliferation Source: MGI
Glomerulus development Source: UniProtKB
Peptide catabolic process Source: GO_Central
Proteolysis Source: GO_Central
Regulation of blood pressure Source: GO_Central
Regulation of systemic arterial blood pressure by renin-angiotensin Source: UniProtKB
Signal transduction Source: GO_Central
Angiotensin maturation Source: UniProtKB
Cell-cell signaling Source: UniProtKB
Cell migration Source: MGI
Cell population proliferation Source: MGI
Glomerulus development Source: UniProtKB
Peptide catabolic process Source: GO_Central
Proteolysis Source: GO_Central
Regulation of blood pressure Source: GO_Central
Regulation of systemic arterial blood pressure by renin-angiotensin Source: UniProtKB
Signal transduction Source: GO_Central
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-18
Helical: 19-39
Extracellular: 40-957
Helical: 19-39
Extracellular: 40-957
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Anti-ENPEP antibodies
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Target: ENPEP
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: 63
Application*: F
Target: ENPEP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 2G11
Application*: E, IH
Target: ENPEP
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBWJC-2117
Application*: IP, F
Target: ENPEP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-0887
Application*: WB, P
Target: ENPEP
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBFYE-0113
Application*: F, IP, IH
Target: ENPEP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-0888
Application*: E, P
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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