ENPEP

ENPEP (Glutamyl Aminopeptidase) is a Protein Coding gene. Diseases associated with ENPEP include Neurogenic Hypertension and Gestational Choriocarcinoma. Among its related pathways are Peptide hormone metabolism and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include peptidase activity and aminopeptidase activity. An important paralog of this gene is ANPEP.

Glutamyl Aminopeptidase

Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.

Angiogenesis Source: UniProtKB
Angiotensin maturation Source: UniProtKB
Cell-cell signaling Source: UniProtKB
Cell migration Source: MGI
Cell population proliferation Source: MGI
Glomerulus development Source: UniProtKB
Peptide catabolic process Source: GO_Central
Proteolysis Source: GO_Central
Regulation of blood pressure Source: GO_Central
Regulation of systemic arterial blood pressure by renin-angiotensin Source: UniProtKB
Signal transduction Source: GO_Central

Cell membrane

Cytoplasmic: 1-18
Helical: 19-39
Extracellular: 40-957