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Mouse Anti-ENPEP Recombinant Antibody (CBFYE-0888) (CBMAB-E1352-FY)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rabbit
Clone
CBFYE-0888
Application
ELISA, IHC-P
Immunogen
A synthesized peptide derived from human ENPEP.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC-P1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, glycerol
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Glutamyl Aminopeptidase
Introduction
ENPEP (Glutamyl Aminopeptidase) is a Protein Coding gene. Diseases associated with ENPEP include Neurogenic Hypertension and Gestational Choriocarcinoma. Among its related pathways are Peptide hormone metabolism and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include peptidase activity and aminopeptidase activity. An important paralog of this gene is ANPEP.
Entrez Gene ID
2028
UniProt ID
Q07075
Alternative Names
Glutamyl Aminopeptidase; Differentiation Antigen Gp160; Aminopeptidase A; EC 3.4.11.7; AP-A; EAP; Glutamyl Aminopeptidase (Aminopeptidase A)
Research Area
Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.
Biological Process
Angiogenesis Source: UniProtKB
Angiotensin maturation Source: UniProtKB
Cell-cell signaling Source: UniProtKB
Cell migration Source: MGI
Cell population proliferation Source: MGI
Glomerulus development Source: UniProtKB
Peptide catabolic process Source: GO_Central
Proteolysis Source: GO_Central
Regulation of blood pressure Source: GO_Central
Regulation of systemic arterial blood pressure by renin-angiotensin Source: UniProtKB
Signal transduction Source: GO_Central
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-18
Helical: 19-39
Extracellular: 40-957

Wang, A., Chu, H., Jin, Z., Gong, Z., Jia, Q., & Zhu, B. (2022). ENPEP as a potential predictor of immune checkpoint inhibitor efficacy. Cancer Medicine, 11(3), 880-887.

Aung, M., Konoshita, T., Moodley, J., Naicker, T., Connolly, C., Khaliq, O. P., & Gathiram, P. (2021). Aminopeptidase A (ENPEP) gene polymorphisms and preeclampsia: Descriptive analysis. European Journal of Obstetrics & Gynecology and Reproductive Biology, 258, 70-74.

Berillo, O., Ouerd, S., Idris-Khodja, N., Rehman, A., Richer, C., Sinnett, D., ... & Schiffrin, E. L. (2021). Chromosome 2 fragment substitutions in Dahl salt-sensitive rats and RNA sequencing identified Enpep and Hs2st1 as vascular inflammatory modulators. Hypertension, 77(1), 178-189.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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