ERAP1

The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

Full Name

Endoplasmic Reticulum Aminopeptidase 1

Research Area

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

Biological Process

Adaptive immune response Source: UniProtKB-KW
Angiogenesis Source: HGNC-UCL
Antigen processing and presentation of endogenous peptide antigen via MHC class I Source: HGNC-UCL
Antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
Fat cell differentiation Source: UniProtKB
Membrane protein ectodomain proteolysis Source: UniProtKB
Peptide catabolic process Source: GO_Central
Positive regulation of angiogenesis Source: Ensembl
Proteolysis Source: GO_Central
Regulation of blood pressure Source: GO_Central
Regulation of innate immune response Source: UniProtKB
Response to bacterium Source: BHF-UCL
Signal transduction Source: GO_Central

Cellular Location

Endoplasmic reticulum membrane

Topology

Cytoplasmic: 1
Helical: 2-21
Lumenal: 22-941

PTM

N-glycosylated.