FKBP8

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]

Full Name

FK506 Binding Protein 8

Function

Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.

Biological Process

Apoptotic process Source: UniProtKB-KW
Camera-type eye development Source: Ensembl
Cell fate specification Source: Ensembl
Dorsal/ventral neural tube patterning Source: Ensembl
Intracellular signal transduction Source: ProtInc
Multicellular organism growth Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of protein phosphorylation Source: CAFA
Positive regulation of BMP signaling pathway Source: Ensembl
Protein folding Source: MGI
Regulation of gene expression Source: Ensembl
Smoothened signaling pathway Source: Ensembl

Cellular Location

Mitochondrion; Mitochondrion membrane
Isoform 1: Mitochondrion membrane
Isoform 3: Mitochondrion membrane

Topology

Helical: 390-410

PTM

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.