Mouse Anti-FKBP8 Recombinant Antibody (CBXF-2646) (V2LY-0925-LY2113)

Name: Mouse Anti-FKBP8 Recombinant Antibody (CBXF-2646)
SKU: V2LY-0925-LY2113
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-FKBP8 Recombinant Antibody (CBXF-2646) (V2LY-0925-LY2113) in Immunoblot

Immunoblot analyses of BNIP3, NIX, BCL2L13, FKBP8, and FUNDC1 in WT and B/N DKO cells under DFP treatment. ...View More

Yamashita, S. I., Arai, R., Hada, H., Padman, B. S., Lazarou, M., Chan, D. C., ... & Waguri, S. (2025). The mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to mitochondria. Journal of Cell Biology, 224(7), e202408166.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-2646

Application

Immunogen

E. coli-derived recombinant human FKBP38 (Met58-Gly382).

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

Application	Note
WB	0.5 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS & Trehalose

Preservative

None

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

FK506 Binding Protein 8

Entrez Gene ID

Human	23770
Mouse	14232
Rat	290652

UniProt ID

Human	Q14318
Mouse	O35465
Rat	Q3B7U9

Function

Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.

Biological Process

Apoptotic process Source: UniProtKB-KW
Camera-type eye development Source: Ensembl
Cell fate specification Source: Ensembl
Dorsal/ventral neural tube patterning Source: Ensembl
Intracellular signal transduction Source: ProtInc
Multicellular organism growth Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of protein phosphorylation Source: CAFA
Positive regulation of BMP signaling pathway Source: Ensembl
Protein folding Source: MGI
Regulation of gene expression Source: Ensembl
Smoothened signaling pathway Source: Ensembl

Cellular Location

Mitochondrion; Mitochondrion membrane
Isoform 1: Mitochondrion membrane
Isoform 3: Mitochondrion membrane

Topology

Helical: 390-410

PTM

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

Zuo, L., Kuo, W. T., Cao, F., Chanez-Paredes, S. D., Zeve, D., Mannam, P., ... & Turner, J. R. (2022). Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn’s disease. Gut.

Aguilera, M. O., Robledo, E., Melani, M., Wappner, P., & Colombo, M. I. (2022). FKBP8 is a novel molecule that participates in the regulation of the autophagic pathway. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1869(5), 119212.

Lv, S., Zhao, X., Zhang, E., Yan, Y., Ma, X., Li, N., ... & Song, T. (2022). Lysine demethylase KDM1A promotes cell growth via FKBP8–BCL2 axis in hepatocellular carcinoma. Journal of Biological Chemistry, 298(9).

Zhang, J., Yin, Y., Wang, J., Zhang, J., Liu, H., Feng, W., ... & Xu, Y. (2021). Prohibitin regulates mTOR pathway via interaction with FKBP8. Frontiers of Medicine, 15, 448-459.

Yoo, S. M., Yamashita, S. I., Kim, H., Na, D., Lee, H., Kim, S. J., ... & Jung, Y. K. (2020). FKBP8 LIRL‐dependent mitochondrial fragmentation facilitates mitophagy under stress conditions. The FASEB Journal, 34(2), 2944-2957.

Tian, T., Cao, X., Kim, S. E., Lin, Y. L., Steele, J. W., Cabrera, R. M., ... & Lei, Y. (2020). FKBP8 variants are risk factors for spina bifida. Human molecular genetics, 29(18), 3132-3144.

Hsu, F. F., Chou, Y. T., Chiang, M. T., Li, F. A., Yeh, C. T., Lee, W. H., & Chau, L. Y. (2019). Signal peptide peptidase promotes tumor progression via facilitating FKBP8 degradation. Oncogene, 38(10), 1688-1701.

Xu, S. S., Xu, L. G., Yuan, C., Li, S. N., Chen, T., Wang, W., ... & Rao, H. (2019). FKBP8 inhibits virus‐induced RLR‐VISA signaling. Journal of Medical Virology, 91(3), 482-492.

Peng, Y. J., Lee, Y. C., Fu, S. J., Chien, Y. C., Liao, Y. F., Chen, T. Y., ... & Tang, C. Y. (2018). FKBP8 enhances protein stability of the CLC-1 chloride channel at the plasma membrane. International journal of molecular sciences, 19(12), 3783.

Misaka, T., Murakawa, T., Nishida, K., Omori, Y., Taneike, M., Omiya, S., ... & Otsu, K. (2018). FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice. Journal of Molecular and Cellular Cardiology, 114, 93-104.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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