FUCA1

The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.[provided by RefSeq, Oct 2009]
Full Name
Alpha-L-Fucosidase 1
Function
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
Biological Process
Fucose metabolic process Source: UniProtKB
Glycolipid catabolic process Source: BHF-UCL
Glycosaminoglycan catabolic process Source: UniProtKB
Glycoside catabolic process Source: UniProtKB
Cellular Location
Lysosome
Involvement in disease
Fucosidosis (FUCA1D):
An autosomal recessive lysosomal storage disease characterized by accumulation of fucose-containing glycolipids and glycoproteins in various tissues. Clinical signs include facial dysmorphism, dysostosis multiplex, moderate hepatomegaly, severe intellectual deficit, deafness, and according to age, angiokeratomas.
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Anti-FUCA1 antibodies

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Mouse Anti-FUCA1 Recombinant Antibody (CBYC-A958) (CBMAB-A4411-YC)

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Target: FUCA1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-A958
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-FUCA1 Recombinant Antibody (1D4) (CBMAB-A4409-YC)

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Target: FUCA1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1D4
Application*: E, WB
Datasheet SDS

Mouse Anti-FUCA1 Recombinant Antibody (CBXF-0955) (CBMAB-F0992-CQ)

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Target: FUCA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-0955
Application*: WB
Datasheet SDS

Mouse Anti-FUCA1 Recombinant Antibody (CBYJT-1284) (CBMAB-T0299-YJ)

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Target: FUCA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1284
Application*: WB
Datasheet SDS

Mouse Anti-FUCA1 Recombinant Antibody (CBYC-A959) (CBMAB-A4412-YC)

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Target: FUCA1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYC-A959
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-FUCA1 (AA 32-466) Recombinant Antibody (CBXF-3232) (CBMAB-F3927-CQ)

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Target: FUCA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3232
Application*: E, WB
Datasheet SDS

Rabbit Anti-FUCA1 Recombinant Antibody (CBXF-1101) (CBMAB-F0993-CQ)

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Target: FUCA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBXF-1101
Application*: WB, F
Datasheet SDS

FUCA1 Matched Antibody Pair (456) (APMAB-456LY)

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Target: FUCA1
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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