FXYD3
This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Full Name
FXYD Domain Containing Ion Transport Regulator 3
Function
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na+ out of the cell and K+ into the cell (PubMed:17077088).
Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534).
Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (PubMed:7836447).
Isoform 1:
Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials.
Isoform 2:
Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials.
Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534).
Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (PubMed:7836447).
Isoform 1:
Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials.
Isoform 2:
Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials.
Biological Process
Chloride transport Source: ProtInc
Potassium ion transport Source: UniProtKB-KW
Regulation of sodium ion transmembrane transporter activity Source: GO_Central
Sodium ion transport Source: UniProtKB-KW
Potassium ion transport Source: UniProtKB-KW
Regulation of sodium ion transmembrane transporter activity Source: GO_Central
Sodium ion transport Source: UniProtKB-KW
Cellular Location
Cell membrane
Topology
Extracellular: 21-38
Helical: 39-59
Cytoplasmic: 60-87
Helical: 39-59
Cytoplasmic: 60-87
PTM
Glutathionylated.
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Anti-FXYD3 antibodies
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CompareTarget: FXYD3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-3612
Application*: WB, IF, IH
Target: FXYD3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse, Rat
Clone: CBXF-3610
Application*: WB, IP, IF, E
Target: FXYD3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Rat
Clone: 4E3
Application*: WB, IP, IF, E
Target: FXYD3
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Mouse, Rat
Clone: CBXF-3557
Application*: WB, IP, IF, E
Target: FXYD3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-3550
Application*: WB, IP, IF, E
Target: FXYD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3562
Application*: WB, IF, IH
Target: FXYD3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1142
Application*: WB, P, F, IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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