GABPB1

This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Ga Binding Protein Transcription Factor Beta Subunit 1

Transcription factor capable of interacting with purine rich repeats (GA repeats) (PubMed:8441384, PubMed:10675337, PubMed:8816484).

Acts as a a master regulator of nuclear-encoded mitochondrial genes (By similarity).

(Microbial infection) Necessary for the expression of the Adenovirus E4 gene.

Mitochondrion organization Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: MGI

Nucleus

Acetylated by EP300/p300. Deacetylated by SIRT7, promoting heterotetramerization and activity.