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GALP

This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction.

Full Name

Galanin Like Peptide

Function

Isoform 1:
Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.

Isoform 2:
Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2. Exhibits antimicrobial activity against Gram-negative bacterias, inducing bacterial membrane blebbing (PubMed:23537644).

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Behavioral response to starvation Source: GO_Central
Defense response to Gram-negative bacterium Source: UniProtKB
Modulation of process of other organism Source: UniProtKB
Neuropeptide signaling pathway Source: UniProtKB-KW
Regulation of appetite Source: Ensembl
Response to insulin Source: Ensembl

Cellular Location

Secreted

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Anti-GALP antibodies

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Mouse Galp ELISA Kit (V2LY-0626-LY5853)

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Target: Galp

Sensitivity: 0.0075 ng/mL

Detection Range: 0.015-3 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Mouse

Assay Type: Sandwich

Reactivity: Mouse

Mouse Galp ELISA Kit

Human GALP ELISA Kit (V2LY-0626-LY4210)

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Target: GALP

Sensitivity: 0.022 ng/mL

Detection Range: 0.05-10 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Human GALP ELISA Kit

Rabbit Anti-GALP Recombinant Antibody (BA0087) (CBMAB-0327CQ)

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Target: GALP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: BA0087

Application*: WB

Rabbit Anti-GALP Recombinant Antibody (BA0087)

Rabbit Anti-GALP Recombinant Antibody (BA0088) (CBMAB-0326CQ)

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Target: GALP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: BA0088

Application*: WB

Rabbit Anti-GALP Recombinant Antibody (BA0088)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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