GALP

This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction.

Full Name

Galanin Like Peptide

Function

Isoform 1:
Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.

Isoform 2:
Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2. Exhibits antimicrobial activity against Gram-negative bacterias, inducing bacterial membrane blebbing (PubMed:23537644).

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Behavioral response to starvation Source: GO_Central
Defense response to Gram-negative bacterium Source: UniProtKB
Modulation of process of other organism Source: UniProtKB
Neuropeptide signaling pathway Source: UniProtKB-KW
Regulation of appetite Source: Ensembl
Response to insulin Source: Ensembl

Cellular Location

Secreted