GCHFR

GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.

Full Name

GTP cyclohydrolase I feedback regulator

Function

Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.

Biological Process

Negative regulation of biosynthetic process Source: InterPro
Negative regulation of GTP cyclohydrolase I activity Source: GO_Central
Neurotransmitter metabolic process Source: ProtInc
Nitric oxide biosynthetic process Source: ProtInc
Protein-containing complex assembly Source: Ensembl

Cellular Location

Nucleus; Nucleus membrane; Cytosol

Anti-GCHFR antibodies

Mouse Anti-GCHFR Recombinant Antibody (CBLG1-3154) (CBMAB-G2613-LY)

Datasheet

SDS

Target: GCHFR

Host: Mouse

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBLG1-3154

Application*: WB

Rabbit Anti-GCHFR Recombinant Antibody (EG1299) (CBMAB-EN1571-LY)

Datasheet

SDS

Target: GCHFR

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG1299

Application*: IHC: 1:50~1:100 ELISA: 1:10000

Mouse Anti-GCHFR Monoclonal Antibody (4G6) (CBMAB-1326-YC)

Datasheet

SDS

Target: GCHFR

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 4G6

Application*: E, IF

Mouse Anti-GCHFR Recombinant Antibody (CBLNG-179) (CBMAB-1565-CN)

Datasheet

SDS

Target: GCHFR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLNG-179

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)