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GCHFR

GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.

Full Name

GTP cyclohydrolase I feedback regulator

Function

Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.

Biological Process

Negative regulation of biosynthetic process Source: InterPro
Negative regulation of GTP cyclohydrolase I activity Source: GO_Central
Neurotransmitter metabolic process Source: ProtInc
Nitric oxide biosynthetic process Source: ProtInc
Protein-containing complex assembly Source: Ensembl

Cellular Location

Nucleus; Nucleus membrane; Cytosol

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Anti-GCHFR antibodies

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Mouse Anti-GCHFR Recombinant Antibody (CBLG1-3154) (CBMAB-G2613-LY)

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Target: GCHFR

Host: Mouse

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBLG1-3154

Application*: WB

Mouse Anti-GCHFR Recombinant Antibody (CBLNG-179) (CBMAB-1565-CN)

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Target: GCHFR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLNG-179

Application*: WB

Mouse Anti-GCHFR Monoclonal Antibody (4G6) (CBMAB-1326-YC)

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Target: GCHFR

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 4G6

Application*: E, IF

Mouse Anti-GCHFR Recombinant Antibody (EG1299) (V2LY-1225-LY900)

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Target: GCHFR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: EG1299

Application*: WB

Mouse Anti-GCHFR Recombinant Antibody (CBLG1-3154) (V2LY-1225-LY899)

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Target: GCHFR

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBLG1-3154

Application*: WB, IP, IF, E

Mouse Anti-GCHFR Recombinant Antibody (CBLNG-179) (V2LY-1225-LY898)

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Target: GCHFR

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human, Mouse, Rat

Clone: CBLNG-179

Application*: WB, IP, IF, E

Mouse Anti-GCHFR Recombinant Antibody (4G6) (V2LY-1225-LY897)

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Target: GCHFR

Host: Mouse

Antibody Isotype: IgG2, κ

Specificity: Human

Clone: 4G6

Application*: WB, IH

Rabbit Anti-GCHFR Recombinant Antibody (EG1299) (CBMAB-EN1571-LY)

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Target: GCHFR

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG1299

Application*: IHC: 1:50~1:100 ELISA: 1:10000

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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