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Mouse Anti-GCHFR Monoclonal Antibody (4G6) (CBMAB-1326-YC)

Provided herein is a mouse monoclonal antibody against Human GCHFR. The antibody, clone 4G6, can be used for immunoassay techniques, such as ELISA and IF.
See all GCHFR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4G6
Antibody Isotype
IgG2b
Application
ELISA, IF

Basic Information

Immunogen
Partial recombinant protein GCHFR (NP_005249.1, aa 1-84) with GST tag
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
GTP cyclohydrolase I feedback regulator
Introduction
GCHFR binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I, which consists of a homodimer. GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.
Entrez Gene ID
2644
UniProt ID
P30047
Alternative Names
P35; GFRP; HsT16933
Function
Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
Biological Process
Negative regulation of biosynthetic process Source: InterPro
Negative regulation of GTP cyclohydrolase I activity Source: GO_Central
Neurotransmitter metabolic process Source: ProtInc
Nitric oxide biosynthetic process Source: ProtInc
Protein-containing complex assembly Source: Ensembl
Cellular Location
Nucleus; Nucleus membrane; Cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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