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Rabbit Anti-GCHFR Recombinant Antibody (EG1299) (CBMAB-EN1571-LY)

The product is antibody recognizes GCHFR. The antibody EG1299 immunoassay techniques such as: IHC: 1:50~1:100 ELISA: 1:10000.
See all GCHFR antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG1299
Antibody Isotype
IgG
Application
IHC: 1:50~1:100 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human GCHFR.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GTP cyclohydrolase I feedback regulator
Introduction
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.
Entrez Gene ID
Human2644
Mouse320415
Rat171128
UniProt ID
HumanP30047
MouseP99025
RatP70552
Alternative Names
P35; GFRP; HsT16933
Function
Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
Biological Process
Negative regulation of biosynthetic process Source: InterPro
Negative regulation of GTP cyclohydrolase I activity Source: GO_Central
Neurotransmitter metabolic process Source: ProtInc
Nitric oxide biosynthetic process Source: ProtInc
Protein-containing complex assembly Source: Ensembl
Cellular Location
Nucleus; Nucleus membrane; Cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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